Results 111 to 120 of about 2,079,774 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Generating synthetic population for simulating the spatiotemporal dynamics of epidemics

PLOS Computational Biology
Agent-based models have gained traction in exploring the intricate processes governing the spread of infectious diseases, particularly due to their proficiency in capturing nonlinear interaction dynamics. The fidelity of agent-based models in replicating real-world epidemic scenarios hinges on the accurate portrayal of both population-wide and ...
Kemin Zhu, Kang Liu, Junli Liu, Yong Shi, Xuan Li, Hanfa Zou, Huibin Du, Ling Yin   +7 more
openaire   +3 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A note on fractional-type models of population dynamics

Mathematical Modelling and Analysis
The fractional exponential function is considered. General expansions in fractional powers are used to solve fractional population dynamics problems. Laguerretype exponentials are also considered, and an application to Laguerre-type fractional logistic ...
Diego Caratelli, Paolo Emilio Ricci
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Internal Migration and Regional Population Dynamics in Europe: Czech Case Study [PDF]

, 1998
Report prepared for the Council of Europe (Directorate of Social and Economic Affairs, Population and Migration Division) and for European Commission (Directorate General V, Employment, Industrial Relations and Social Affairs, Unit E1, Analysis and ...
Dusan Drbohlav, Helen Durham, Leeds Ls Jt, Marek Kupiszewski, Philip Rees   +4 more
core   +2 more sources

Dynamics of Encoding in Neuron Populations: Some General Mathematical Features

Neural Computation, 2000
The use of a population dynamics approach promises efficient simulation of large assemblages of neurons. Depending on the issues addressed and the degree of realism incorporated in the simulated neurons, a wide range of different population dynamics formulations can be appropriate.
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Coexistence of a general elliptic system in population dynamics

Computers & Mathematics with Applications, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Lin, Zhigui, Pedersen, M.
openaire   +1 more source