Results 121 to 130 of about 7,668,561 (373)

Convergence of generalized urn models to non-equilibrium attractors

, 2014
Generalized Polya urn models have been used to model the establishment dynamics of a small founding population consisting of k different genotypes or strategies.
Faure, Mathieu, Schreiber, Sebastian
core   +3 more sources

Patterns of distribution, population genetics and ecological requirements of field-occurring resistant and susceptible Pseudosuccinea columella snails to Fasciola hepatica in Cuba [PDF]

, 2019
Annia Alba, Antonio A. Vázquez, Jorge Sánchez, Manon Lounnas, Jean-Pierre Pointier, Sylvie Hurtrez‐Boussès, Benjamin Gourbal   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Towards the Human Genotope [PDF]

, 2006
The human genotope is the convex hull of all allele frequency vectors that can be obtained from the genotypes present in the human population. In this paper we take a few initial steps towards a description of this object, which may be fundamental for ...
Huggins, Peter, Pachter, Lior, Sturmfels, Bernd   +2 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genetic evidence of population structuring in the neotropical freshwater fish Brycon hilarii (Valenciennes, 1850)

Brazilian Journal of Biology
Brycon hilarii is a migratory fish widely distributed throughout the Paraguay River Basin. It is appreciated in sport fishing and for its superior meat quality. It is also the main species for tourist attraction in the Bonito region (State of Mato Grosso
A Sanches, PM. Galetti Jr
doaj   +1 more source

POPULATION GENETICS OF DROSOPHILA AMYLASE. V. GENETIC BACKGROUND AND SELECTION ON DIFFERENT CARBOHYDRATES [PDF]

, 1984
Jeffrey R. Powell, George Amato
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Efficient Forward Simulation of Fisher-Wright Populations with Stochastic Population Size and Neutral Single Step Mutations in Haplotypes

, 2012
In both population genetics and forensic genetics it is important to know how haplotypes are distributed in a population. Simulation of population dynamics helps facilitating research on the distribution of haplotypes.
Andersen, Mikkel Meyer, Eriksen, Poul Svante   +1 more
core  

Probabilistic investigations of population genetics [PDF]

, 1955
Yûsaku Komatu
openalex   +1 more source