Results 231 to 240 of about 6,085,455 (294)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Correction: Population genetics of <i>Plasmodium vivax</i> with transmission decline and rebound in two endemic areas of Papua New Guinea. [PDF]

Front Genet
Fola AA, Mehra S, Razook Z, Lautu-Gumal D, Nate E, Lee S, Kattenberg JH, Koepfli C, Kazura J, Ome-Kaius M, Laman M, Robinson LJ, Mueller I, Barry AE.   +13 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Opinion: Why Sex-Based Genomic Differentiation Should Not Be Overlooked in Population Genetics. [PDF]

Mol Ecol
Chen YC, Vellnow N, Wilcox JJS, Javaheri Tehrani S, Gossmann TI.   +4 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

demografr : A toolkit for simulation-based inference in population genetics

Petr M, Pötzsch IM, Racimo F.
europepmc   +1 more source

Benchmarking of variant pathogenicity prediction methods using a population genetics approach. [PDF]

Bioinform Adv
Gudkov M, Thibaut L, Monger S, Das D, Winlaw DS, Dunwoodie SL, Giannoulatou E, Congenital Heart Disease Synergy Study Group .   +7 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Population Genetics Reveals the Invasion Pathways of <i>Mesembryanthemum nodiflorum</i> in North America. [PDF]

Ecol Evol
van Steenderen CJM, Sandenbergh E, Brookes D, Moran PJ, Cristofaro M, Hoyer WF, Paterson ID.   +6 more
europepmc   +1 more source