Results 81 to 90 of about 1,325,954 (330)

Exploring a Pool‐seq‐only approach for gaining population genomic insights in nonmodel species

Ecology and Evolution, 2019
Developing genomic insights is challenging in nonmodel species for which resources are often scarce and prohibitively costly. Here, we explore the potential of a recently established approach using Pool‐seq data to generate a de novo genome assembly for ...
Sara Kurland, Christopher W. Wheat, Maria de laPaz Celorio Mancera, Verena E. Kutschera, Jason Hill, Anastasia Andersson, Carl‐Johan Rubin, Leif Andersson, Nils Ryman, Linda Laikre   +9 more
doaj   +1 more source

Genetic Structure of the Spanish Population [PDF]

BMC Genomics, 2010
Abstract Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.
Ana Salinas, Javier Gayán, Antonio González-Pérez, María Dolores Ochoa, José Miguel Carrasco, Juan Velasco, Juan Luis Susillo-González, Eva Molero, Carolina Ochoa, Concha Moreno-Rey, Jose Luis Royo, Mercedes Reina, Marta Gutierrez, Reposo Ramírez-Lorca, Carina Zabena, Agustín Ruiz, José Jorge Galán, Francisco J. Morón, Alejandro Romo-Astorga, María Teresa Martínez-Larrad, Rocío Pascual, Luis Miguel Real, Manuel Serrano-Ríos, Enrique Vazquez, M Carmen Rivero, María Eugenia Sáez   +25 more
openaire   +5 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Unraveling the Complexity of the Ne/Nc Ratio for Conservation of Large and Widespread Pelagic Fish Species: Current Status and Challenges

Evolutionary Applications
Estimating and understanding the ratio between effective population size (Ne) and census population size (Nc) are pivotal in the conservation of large marine pelagic fish species, including bony fish such as tunas and cartilaginous fish such as sharks ...
Chrystelle Delord, Sophie Arnaud‐Haond, Agostino Leone, Jonathan Rolland, Natacha Nikolic   +4 more
doaj   +1 more source

Population genetics models of local ancestry

, 2012
Migrations have played an important role in shaping the genetic diversity of human populations. Understanding genomic data thus requires careful modeling of historical gene flow.
Falush, Li, Simon Gravel
core   +1 more source

The effect of recurrent mutations on genetic diversity in a large population of varying size [PDF]

, 2016
Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the new mutation.
Smadi, Charline
core   +3 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Improved allele frequencies in gnomAD through local ancestry inference

Nature Communications
The Genome Aggregation Database (gnomAD) is a foundational resource for allele frequency data, widely used in genomic research and clinical interpretation.
Pragati Kore, Michael W. Wilson, Grace Tiao, Katherine Chao, Philip W. Darnowsky, Nicholas A. Watts, Jessica Honorato Mauer, Samantha M. Baxter, Genome Aggregation Database Consortium, Heidi L. Rehm, Mark J. Daly, Konrad J. Karczewski, Elizabeth G. Atkinson   +12 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source