Results 151 to 160 of about 661,661 (299)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Population genomics reveals deep diversification in Malayan pangolins. [PDF]

Mol Biol Evol
Li B, Li H, Shi M, Wang Q, Li H, Guo C, Hu J, Liu B, Tian Y, Liu S, Finch K, Wang S, Yang S, Cui L, Li J, Zhao X, Deng Z, Ma Y, Kim HJ, Wasser SK, Wang K, Lu H, Chen J, Guo H, Yao Y, Xie H, Wang Y, Fan J, Lin Y, Hou Y, Fu Y, Jiang C, Lu J, Li S, Qiu Z, Zhang W, Bai S, Han L, Wang Z, Wang C, Li J, Jiang Y, Liu S, Wang J, Yu L, Li Q, Li L, Hua Y, Lan T, Xu Y.   +49 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Association of Chewing Tobacco and the Risk of Breast Cancer in Indian Women: A Multicentre Case-Control Study

International Journal of Breast Cancer
Romi Moirangthem, Ankita Manjrekar, Gayathri B. Pullat, Shruti Vishwas Golapkar, Ruchita Sahdev Margale, Sakshi Sagare, Dipakshi Talukdar, Nandini Chakraborty, Ruchi Pathak, Satyajit Pradhan, Manigreeva Krishnatreya, Nandkumar Panse, Rajesh Dikshit, Isabelle Soerjomataram, Sudeep Gupta, Sharayu Mhatre   +15 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Population Genomics of a Rare and a Common Wood-Inhabiting Fungal Species Across Europe. [PDF]

Mol Ecol
Krah FS, Scharmann M, Weig AR, Hess J, Kellner H, Athanasiadis A, Büttner E, Dvořák D, Holec J, Iršėnaitė R, Junninen K, Krisai-Greilhuber I, Kunca V, Maurice S, Meier J, Mešić A, Miettinen O, Runnel K, Schäfer P, Tkalčec Z, Pouska V, Voglmayr H, Zibold M, Bässler C.   +23 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source