Results 241 to 250 of about 661,661 (299)

Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae. [PDF]

Commun Biol
Chen L, Guo LX, Zhang HM, Sun XN, Liu YT, Ji J, Xue WX, Wybouw N, Van Leeuwen T, Xue XF, Hong XY, Sun JT.   +11 more
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Population Genomics and Morphology Provide Insights into the Conservation and Diversity of <i>Apis laboriosa</i>. [PDF]

Insects
Liu R, Ma X, Zhang L, Lai K, Shu C, Wang B, Zhang M, Yang M.   +7 more
europepmc   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Population Genomics Provides Insights Into Genomic Features of Inbreeding Depression in <i>Arma Chinensis</i>. [PDF]

Evol Appl
Li B, Song K, Wu Z, Zhang X, Li H, Yang L.   +5 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Population Genomics Reveals Demographic History and Climate Adaptation in Japanese Arabidopsis halleri. [PDF]

Plant Cell Physiol
Suda RA, Kubota S, Kumar V, Castric V, Krämer U, Morinaga SI, Tsuchimatsu T.   +6 more
europepmc   +1 more source

Population genomics elucidates the trajectory of chicken domestication from Asia to Japan. [PDF]

Poult Sci
Matsuda Y, Matsumoto Y, Higashiura Y, Bendesky A, Tsudzuki M, Shimmura T.   +5 more
europepmc   +1 more source

Integrating population genomics and environmental data to predict adaptation to climate change in post-bottleneck Tibetan macaques. [PDF]

Sci Adv
Teng Y, Li W, Wang X, Zhang R, Shen Y, Wu R, Liu J, Zhang M, Roos C, Li J, Li J, Qi J, Li M.   +12 more
europepmc   +1 more source

Chromosome-level genome assembly and population genomics analysis of <i>Camellia rubituberculata</i> provide insights into adaptation to karst habitats. [PDF]

Plant Divers
Yan C, An MT, Tang M, Bai XX, Xiao X, Ran ZH, Li Z.   +6 more
europepmc   +1 more source