Results 131 to 140 of about 13,735,667 (283)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Population research in the Pacific Islands : a case study and some reflections [PDF]

, 1971
For more about the East-West Center, see http://www.eastwestcenter.org/This paper outlines the aims and methods (rather than the results) of a study of population movement undertaken in the British Solomon Islands Protectorate between October 1965 and ...
East-West Population Institute, Chapman, Murray   +1 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bottom-up gridded population estimates for Nigeria, version 2.0

This data release provides gridded population estimates (spatial resolution of 3 arc-seconds, approximately 100 m grid cells) with national coverage for Nigeria, along with estimates of the number of people belonging to various age-sex groups.
Lloyd, Christopher, National Population Commission of Nigeria, WorldPop   +2 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Legal regulation of population movement to, from, and within the United States : a survey of current law and constitutional limitations [PDF]

, 1972
For more about the East-West Center, see http://www.eastwestcenter.org/A wide variety of federal and state laws affect population movement both directly and indirectly.
East-West Population Institute, Maggs, Peter B.   +1 more
core   +1 more source

Blood Pressure Control and Anthropometric Differences in Afro-Descendants and Other Ethnic Groups in Hypertensive Brazilian Populations

Global Heart
Background: The prevalence of hypertension (HT) and blood pressure (BP) control varies among ethnic-racial groups, but studies on this issue and correlations between BP and body mass index (BMI) in the black Brazilian population are scarce.
Maicon Borges Euzébio, Priscila Valverde de Oliveira Vitorino, Andréa Araújo Brandão, Eduardo Costa Duarte Barbosa, Audes Diógenes M. Feitosa, Marcus Vinícius Bolivar Malachias, Marco Mota Gomes, Celso Amodeo, Rui Manoel dos Santos Póvoa, Renato Delascio Lopes, Paulo César Brandão Veiga Jardim, Ana Luiza Lima Sousa, Ana Carolina Arantes, Antonio Coca, Weimar Kunz Sebba Barroso   +14 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Prevalence of tuberculosis respiratory symptoms and associated factors in the indigenous populations of Paraguay (2012)

Memorias do Instituto Oswaldo Cruz
BACKGROUND The prevalence of respiratory symptoms and confirmed tuberculosis (TB) among indigenous groups in Paraguay is unknown. METHODS This study assessed the prevalence of respiratory symptoms, confirmed pulmonary TB, and associated socio-economic
Sarita Aguirre, Celia Martínez Cuellar, María Belén Herrero, Gustavo Chamorro Cortesi, Nilda Gimenez de Romero, Mirian Alvarez, Jose Ueleres Braga   +6 more
doaj   +1 more source