Results 241 to 247 of about 3,805,832 (247)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Re-evaluation of silicon dioxide (E 551) as a food additive in foods for infants below 16 weeks of age and follow-up of its re-evaluation as a food additive for uses in foods for all population groups. [PDF]

EFSA J
EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, Castle L, Degen G, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens-Berendsen I, Wright M, Andreoli C, Bastos M, Benford D, Bignami M, Bolognesi C, Cheyns K, Corsini E, Crebelli R, Dusemund B, Fitzgerald R, Gaffet E, Loeschner K, Marcon F, Mast J, Mirat M, Mortensen A, Oomen A, Schlatter J, Turck D, Ulbrich B, Undas A, Vleminckx C, Woelfle D, Woutersen R, Barmaz S, Dino B, Gagliardi G, Levorato S, Mazzoli E, Nathanail A, Rincon AM, Ruggeri L, Smeraldi C, Tard A, Vermeiren S, Gundert-Remy U.   +53 more
europepmc   +1 more source

Hearing and Balance in Healthy Aging Project: Characterization of Hearing, Balance, and Other Associated Disorders in Three Population Groups Aged 55 and Over.

Audiol Neurootol
de Lima JP, Manrique-Huarte R, Ferran S, Mallmann F, Gil DC, Barrenechea BA, Huarte A, Gallego Madrid MA, Manrique M.   +8 more
europepmc   +1 more source

Plain Language Summary of the re-evaluation of silicon dioxide (E 551) as a food additive in foods for infants below 16 weeks of age and follow-up of its re-evaluation as a food additive for uses in foods for all population groups. [PDF]

EFSA J
europepmc   +1 more source