Results 81 to 90 of about 7,825,418 (303)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Determining the Public Health Impact of Climate Change: A National Study Using a Health Impact Assessment Approach in Wales

International Journal of Public Health
Objective: Climate change is recognised as the biggest threat to global health of the 21st century and impacts on health and wellbeing through a range of factors. Due to this, the need to take action in order to protect population health and wellbeing is
Liz Green, Kathryn Ashton, Nerys Edmonds, Michael Fletcher, Sumina Azam, Karen Hughes, Phil Wheater, Mark A. Bellis   +7 more
doaj   +1 more source

Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes? [PDF]

, 2013
The Chacma baboons (Papio ursinus) of the Cape Peninsula are established raiders of human food, leading to widespread conflict between this intelligent, adaptable species and humans.
Van Velden, Julia
core  

Low genetic variability, female-biased dispersal and high movement rates in an urban population of Eurasian badgersMeles meles [PDF]

, 2008
1. Urban and rural populations of animals can differ in their behaviour, both in order to meet their ecological requirements and due to the constraints imposed by different environments.
Bijlsma, Brownstein, Carpenter, Carpenter, Carpenter, Cheeseman, Christian, Clements, Cresswell, da Silva, Davison, Davison, Ditchkoff, Domingo-Roura, Doncaster, Dugdale, Dugdale, Engel, Estes, Evans, Favre, Frantz, Frantz, Frantz, Gottelli, Griffiths, Hardy, Harris, Harris, Huck, Huck, Huck, Kalinowski, Kowalczyk, Kruuk, Langbein, Loiselle, Macdonald, Marmi, Marshall, McKelvey, McKelvey, Miller, Miller, Mills, Page, Pertoldi, Pope, Queller, Raymond, Roper, Rousset, Scheppers, Schley, Smal, Taberlet, Taberlet, Taylor, Tuyttens, Tuyttens, van Oosterhout, Vekemans, Waits, Walsh, Wilberg, Woodroffe, Woodroffe   +66 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Revaccination against COVID-19: Current Status of the Problem

Эпидемиология и вакцинопрофилактика
The considerable success of vaccination against the new coronavirus infection, which has led to a decrease in morbidity and mortality in adults and children, requires the study of the problem of revaccination against SARS-CoV-2. The pathogenic properties
N. P. Andreeva, S. R. Racic, S. V. Lezhenina, T. G. Denisova   +3 more
doaj   +1 more source

Ethnicity, educational attainment, and physical health of older adults in the United States

Aging Medicine, 2019
Objective Minorities’ diminished returns theory suggests that socioeconomic status (SES) resources generate fewer health benefits for racial and ethnic minority groups, compared to the majority group.
Shervin Assari
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source