Results 181 to 190 of about 876,447 (311)

Realizing Blume-Capel Degrees of Freedom with Toroidal Moments in a Ruby Artificial Spin Ice. [PDF]

ACS Nano
Berchialla L, Macauley GM, Museur F, Wang T, Kleibert A, Derlet PM, Heyderman LJ.   +6 more
europepmc   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Metformin in the Horse: Pharmacokinetics and Detection Times Using Monte Carlo Simulations. [PDF]

Drug Test Anal
Jacobs ME, Blea J, Hardy M, McKemie DS, Traynham M, Knych HK.   +5 more
europepmc   +1 more source

Continuous outcome estimation in N‐of‐1 trials for accelerated decision‐making

Epilepsia, EarlyView.
Abstract Objective N‐of‐1 trials aim to determine the therapeutic effect for a single individual. This individualized approach necessitates collecting multiple data points over time through repeated alternating periods of active treatment and a comparator or control condition.
Victoria Defelippe, František Bartoš, Eric‐Jan Wagenmakers, Kees P. J. Braun, Floor E. Jansen, Willem M. Otte   +5 more
wiley   +1 more source

Development of population pharmacokinetic models of total and free piperacillin in critically ill children and young adults for Monte Carlo simulations and model-informed precision dosing. [PDF]

J Antimicrob Chemother
Tang Girdwood S, Hambrick HR, Morales Junior R, Punt N, Tang P, Curry C, Lahni P, Jones R, Stoneman E, Gibson A, Kaplan J.   +10 more
europepmc   +1 more source

Seismic Design of Concrete Dams: An Integrated Risk‐Informed Performance‐Based (RIPB) Framework

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This paper advances the integration of risk‐informed principles into the seismic design of dams—a domain long guided by standards‐based, largely deterministic approaches. While performance‐based earthquake engineering is well established for buildings and bridges, its systematic adoption in dam engineering remains limited. We first address two
M. Amin Hariri‐Ardebili, Larry K. Nuss
wiley   +1 more source

Preclinical pharmacokinetics/pharmacodynamics studies defining the role of ethambutol in <i>Mycobacterium kansasii</i> lung disease. [PDF]

Antimicrob Agents Chemother
Gumbo T, Boorgula GD, Srivastava S.
europepmc   +1 more source

Modeling the Probability of Tsunami Fire Ignition Based on Data From the 2011 Tohoku and 2024 Noto Peninsula Earthquakes, With Recommendations to Reduce Emerging Fire Risk in Tsunami Vertical Evacuation Structures

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Recent tsunamigenic earthquakes in Japan have highlighted the emerging fire hazard triggered by tsunami inundation and its impact on tsunami vertical evacuation (TVE) structures. This new type of fire following earthquake, referred to as “tsunami fires,” may be a potential universal hazard that tsunami‐prone countries face; however, it has not
Tomoaki Nishino
wiley   +1 more source

Diagnostic CT organ dose estimation in whole-body PET/CT examinations-comparison of a patient-specific monte carlo approach and a computational phantom-based CT dosimetry tool. [PDF]

EJNMMI Phys
Verfaillie G, D'Asseler Y, Bacher K.
europepmc   +1 more source

Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem during the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units

Antimicrobial Agents and Chemotherapy, 2015
S. Jaruratanasirikul, S. Thengyai, W. Wongpoowarak, Thitima Wattanavijitkul, Kanyawisa Tangkitwanitjaroen, Waroonrat Sukarnjanaset, Monchana Jullangkoon, Maseetoh Samaeng   +7 more
semanticscholar   +1 more source