Results 81 to 90 of about 1,056,579 (306)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Number of Doses of Systemic Antibiotic Prophylaxis May Be Reduced in Cemented Primary Knee Arthroplasty Irrespective of Use of Antibiotic in the Cement: A Multiregistry-Based Meta-Analysis

JBJS Open Access
Background:. The use of systemic antibiotic prophylaxis (SAP) and antibiotic-loaded bone cement (ALBC) is the accepted practice to reduce the risk of periprosthetic joint infection (PJI) in primary total knee arthroplasty (pTKA). However, practice varies
Tesfaye H. Leta, PhD, Richard N. Chang, MPH, Anne Marie Fenstad, MSc, Stein Atle Lie, PhD, Stein Håkon L. Lygre, PhD, Martin Lindberg-Larsen, PhD, Alma B. Pedersen, PhD, Olav Lutro, MD, Jinny Willis, PhD, Chris Frampton, PhD, Michael Wyatt, MD, Serban Dragosloveanu, MD, Andreea E. Vorovenci, MSc, Dan Dragomirescu, MSc, Håvard Dale, PhD, Geir Hallan, PhD, Jan-Erik Gjertsen, PhD, Heather A. Prentice, PhD, Ove Furnes, PhD, Art Sedrakyan, PhD, Elizabeth W. Paxton, PhD   +20 more
doaj   +1 more source

Statistical Population Register: using administrative in the Canadian Census

International Journal of Population Data Science, 2018
Introduction For a number of years, Statistics Canada has been evaluating the potential of increasing its use of administrative data into its Census Program.
Sylvain Cloutier
doaj   +1 more source

Digit-all: Rare Diseases

European Medical Journal, 2020
Rare diseases are increasingly recognised as a global public health priority and contribute to significant and disproportionately high health system impacts.
Gareth Baynam, Lynsey Chediak, Gemma Bilkey, Dylan Gration, Samuel Agyei Wiafe   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Education and Mobility [PDF]

We show that the length of compulsory education has a causal impact on regional labour mobility. The analysis is based on a quasi-exogenous staged Norwegian school reform, and register data on the whole population.
Kjell Salvanes, Panu Pelkonen, Stephen Machin   +2 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Disability Insurance, Population Health and Employment in Sweden [PDF]

This paper describes the development of population health and disability insurance utilization for older workers in Sweden and analyses the relation between the two.
Jönsson, Lisa, Palme, Mårten, Svensson, Ingemar   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Is one dose of human papillomavirus vaccine as effective as three?: A national cohort analysis

Papillomavirus Research, 2019
Aim: Prophylactic human papillomavirus (HPV) vaccines are highly effective at preventing pre–cancerous cervical lesions when given in a three–dose schedule. Some post–hoc trial data suggest that one dose prevents HPV infection.
Julia ML. Brotherton, Alison Budd, Christopher Rompotis, Natasha Bartlett, Michael J. Malloy, Rachael L. Andersen, Kim AR. Coulter, Peter W. Couvee, Nerida Steel, Gail H. Ward, Marion Saville   +10 more
doaj   +1 more source