Results 1 to 10 of about 8,235,066 (201)

Integral gene drives for population replacement [PDF]

Biology Open, 2019
A first generation of CRISPR-based gene drives has now been tested in the laboratory in a number of organisms, including malaria vector mosquitoes. Challenges for their use in the area-wide genetic control of vector-borne disease have been identified ...
Alexander Nash, Giulia Mignini Urdaneta, Andrea K. Beaghton, Astrid Hoermann, Philippos Aris Papathanos, George K. Christophides, Nikolai Windbichler   +6 more
doaj   +7 more sources

Advancements and Future Prospects of CRISPR-Cas-Based Population Replacement Strategies in Insect Pest Management [PDF]

Insects
Population replacement refers to the process by which a wild-type population of insect pests is replaced by a population possessing modified traits or abilities.
Yu Zhao, Longfeng Li, Liangzi Wei, Yifan Wang, Zhilin Han   +4 more
doaj   +3 more sources

Engineered reproductively isolated species drive reversible population replacement [PDF]

Nature Communications, 2021
There exist only a handful of methods to engineer reproductive barriers in eukaryotes. Here the authors use CRISPR to engineer multiple barriers in D. melanogaster and model their spread.
Anna Buchman, Isaiah Shriner, Ting Yang, Junru Liu, Igor Antoshechkin, John M. Marshall, Michael W. Perry, Omar S. Akbari   +7 more
doaj   +8 more sources

Predicting thresholds for population replacement gene drives [PDF]

BMC Biology
Background Threshold-dependent gene drives (TDGDs) could be used to spread desirable traits through a population, and are likely to be less invasive and easier to control than threshold-independent gene drives. Engineered Genetic Incompatibility (EGI) is
Anna Janzen, Ratnasri Pothula, Adam Sychla, Nathan R. Feltman, Michael J. Smanski   +4 more
doaj   +4 more sources

Language continuity despite population replacement in Remote Oceania. [PDF]

Nat Ecol Evol, 2018
Recent genomic analyses show that the earliest peoples reaching Remote Oceania—associated with Austronesian-speaking Lapita culture—were almost completely East Asian, without detectable Papuan ancestry.
Posth C, Nägele K, Colleran H, Valentin F, Bedford S, Kami KW, Shing R, Buckley H, Kinaston R, Walworth M, Clark GR, Reepmeyer C, Flexner J, Maric T, Moser J, Gresky J, Kiko L, Robson KJ, Auckland K, Oppenheimer SJ, Hill AVS, Mentzer AJ, Zech J, Petchey F, Roberts P, Jeong C, Gray RD, Krause J, Powell A.   +28 more
europepmc   +10 more sources

Ancient genomes indicate population replacement in Early Neolithic Britain. [PDF]

Nat Ecol Evol, 2019
The roles of migration, admixture and acculturation in the European transition to farming have been debated for over 100 years. Genome-wide ancient DNA studies indicate predominantly Aegean ancestry for continental Neolithic farmers, but also variable admixture with local Mesolithic hunter-gatherers.
Brace S, Diekmann Y, Booth TJ, van Dorp L, Faltyskova Z, Rohland N, Mallick S, Olalde I, Ferry M, Michel M, Oppenheimer J, Broomandkhoshbacht N, Stewardson K, Martiniano R, Walsh S, Kayser M, Charlton S, Hellenthal G, Armit I, Schulting R, Craig OE, Sheridan A, Parker Pearson M, Stringer C, Reich D, Thomas MG, Barnes I.   +26 more
europepmc   +10 more sources

Chapter 9 Gene Drive Strategies for Population Replacement [PDF]

, 2016
Gene drive systems are selfish genetic elements capable of spreading into a population despite a fitness cost. A variety of these systems have been proposed for spreading disease-refractory genes into mosquito populations, thus reducing their ability to ...
Akbari, Omar S, Marshall, John M
core   +6 more sources

<i>Wolbachia</i>-Virus interactions and arbovirus control through population replacement in mosquitoes. [PDF]

Pathog Glob Health, 2023
Following transfer into the primary arbovirus vector Aedes aegypti, several strains of the intracellular bacterium Wolbachia have been shown to inhibit the transmission of dengue, Zika, and chikungunya viruses, important human pathogens that cause ...
Ant TH, Mancini MV, McNamara CJ, Rainey SM, Sinkins SP.   +4 more
europepmc   +2 more sources

Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study. [PDF]

Malar J, 2022
Gene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a promising new vector control strategy to reinvigorate the fight against malaria in sub-Saharan Africa.
Leung S, Windbichler N, Wenger EA, Bever CA, Selvaraj P.   +4 more
europepmc   +2 more sources

Current Effector and Gene-Drive Developments to Engineer Arbovirus-Resistant Aedes aegypti (Diptera: Culicidae) for a Sustainable Population Replacement Strategy in the Field. [PDF]

J Med Entomol, 2021
Arthropod-borne viruses (arboviruses) such as dengue, Zika, and chikungunya viruses cause morbidity and mortality among human populations living in the tropical regions of the world.
Reid WR, Olson KE, Franz AWE.
europepmc   +2 more sources