Results 141 to 150 of about 8,235,165 (300)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A diminishing population whose every cohort more than replaces itself
Demographic Research, 2003 We observe that a dynamic population model can have period fertility that is always below replacement and cohort fertility that is always above replacement.
doaj
On the Impact of Spatial Momentum [PDF]
Momentum, the population growth that occurs after a fall in fertility to replacement level, has long been appreciated as a factor in the future population growth of many countries. This paper argues that another aspect of growing populations - their high
Robert Schoen
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Social Policy Trends: Canada and U.S. Fertility Rates,1920-2018
The School of Public Policy Publications, 2019 The figure shows the fertility rate in Canada and the United States for each year from 1920 to 2018. The fertility rate measures the average number of children that would be born to each woman with prevailing age-specific fertility rates.
Ronald Kneebone
doaj
Socio-economic inequality in small area use of elective total hip replacement in the English NHS in 1991 and 2001 [PDF]
International evidence suggests that there are substantial socio-economic inequalities in the delivery of specialist health services, even in the UK and other high-income countries with publicly funded health systems (Goddard and Smith 2001, Dixon et al.
Geoffrey Hardman +2 more
core
On the inclusion probabilities in some unequal probability sampling plans without replacement
, 2012 Comparison results are obtained for the inclusion probabilities in some unequal probability sampling plans without replacement. For either successive sampling or H\'{a}jek's rejective sampling, the larger the sample size, the more uniform the inclusion ...
Yu, Yaming
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The effects of aging population on the sustainability of fiscal policy [PDF]
We study the effects of aging population on the sustainability of fiscal policy in overlapping generations models with government debt and a pay-as-you-go pension system.
Puhakka , Mikko
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source