Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Gene drive designs for efficient and localisable population suppression using Y-linked editors. [PDF]
PLoS Genet, 2022 Geci R, Willis K, Burt A.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Effects of Maize Density and Sowing Pattern on Weed Suppression and Maize Grain Yield [PDF]
Pesticidi i Fitomedicina, 2007 Plant competition in its basic sense can be defined as competition for resources such as light, water and nutrients. The intensity of crop competition, especially competition of row crops such as maize, mostly depends on population density and plant ...
Milena Simić, Lidija Stefanović
doaj
Medfly Population Suppression through Augmentative Release of an Introduced Parasitoid in an Irrigated Multi-Fruit Orchard of Central-Western Argentina. [PDF]
Insects, 2023 Suárez L +10 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii. [PDF]
Proc Natl Acad Sci U S A, 2023 Yadav AK +5 more
europepmc +1 more source
Suppression of accretion onto low-mass Population III stars
, 2010 9 pages; 2 figures; MNRAS ...
Johnson, J., Khochfar, S.
openaire +3 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
HIV viral suppression in the era of dolutegravir use: Findings from a national survey in Tanzania.
PLoS ONEBackgroundTanzania has made significant progress in improving access to HIV care and treatment. However, virologic suppression among people living with HIV (PLHIV) has not been fully realized.
Doreen Kamori +20 more
doaj +1 more source