Results 141 to 150 of about 575,455 (267)

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Epidemiological characteristics and co-occurrence patterns of <i>Rothia</i> species and respiratory pathogens: from population surveillance to mechanistic insights. [PDF]

J Oral Microbiol
Wang Z, Fang Y, Li J, Li J, Zhu X, Tian R, Chen K, Xiao Y, Zhang L, Liu J.   +9 more
europepmc   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Associated uncertainty estimation during the validation process of TCID₅₀ and FRNT neutralization assays against SARS-CoV-2 variants, used in population surveillance research and correlates of protection. [PDF]

Front Immunol
Reyna-Rosas E, Nieto-Ponce M, Palencia-Reyes A, Blancas-Ruíz C, Carranza C, Torres M, Zamudio-Meza H.   +6 more
europepmc   +1 more source

[Surveillance of Tick Population in the Republic of Korea, 2023].

Jugan geon-gang gwa jilbyeong
Ticks are important vectors of infectious diseases, transmitting viral, bacterial, and protozoan pathogens to humans. Among tick-borne diseases, severe fever thrombocytopenia syndrome (SFTS), which was first discovered in China in 2009, has been designated as a class 3 legal infectious disease in the Republic of Korea (ROK), where it was first reported
Noh, Byung-Eon, Kim, Hyunwoo, Ju, Jung-Won, Lee, Hee-Il   +3 more
openaire   +1 more source

Translating science to inform global policy on physical activity

Journal of Sport and Health Science, 2018
Fiona Bull
doaj   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Household crowding and mortality before and during the COVID-19 pandemic among adults: Findings from longitudinal population surveillance data in rural and peri-urban settings in Limpopo, South Africa. [PDF]

Popul Health Metr
Seakamela KP, Bashingwa JJH, Tlouyamma J, Ntimana CB, Mphekgwana MP, Mashaba RG, Mothapo K, Kabudula CW, Maimela E.   +8 more
europepmc   +1 more source

Use of the Demographic and Health Survey framework as a population surveillance strategy for COVID-19. [PDF]

Lancet Glob Health, 2020
Subramanian SV, James KS.
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source