Results 171 to 180 of about 5,987,732 (303)

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

A Standardized Statistical Framework for Population Surveillance Using the National Health Interview Survey. [PDF]

JACC Adv
Arun AS, Shah RM, Lu Y, Dhruva SS, Krumholz HM.   +4 more
europepmc   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

Epidemiological characteristics and co-occurrence patterns of <i>Rothia</i> species and respiratory pathogens: from population surveillance to mechanistic insights. [PDF]

J Oral Microbiol
Wang Z, Fang Y, Li J, Li J, Zhu X, Tian R, Chen K, Xiao Y, Zhang L, Liu J.   +9 more
europepmc   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Associated uncertainty estimation during the validation process of TCID₅₀ and FRNT neutralization assays against SARS-CoV-2 variants, used in population surveillance research and correlates of protection. [PDF]

Front Immunol
Reyna-Rosas E, Nieto-Ponce M, Palencia-Reyes A, Blancas-Ruíz C, Carranza C, Torres M, Zamudio-Meza H.   +6 more
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Translating science to inform global policy on physical activity

Journal of Sport and Health Science, 2018
Fiona Bull
doaj   +1 more source

Household crowding and mortality before and during the COVID-19 pandemic among adults: Findings from longitudinal population surveillance data in rural and peri-urban settings in Limpopo, South Africa. [PDF]

Popul Health Metr
Seakamela KP, Bashingwa JJH, Tlouyamma J, Ntimana CB, Mphekgwana MP, Mashaba RG, Mothapo K, Kabudula CW, Maimela E.   +8 more
europepmc   +1 more source