Results 231 to 240 of about 8,679,721 (347)

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Estimating the sensitivity of passive surveillance for HPAI H5N1 in Bayelsa state, Nigeria. [PDF]

, 2016
Adene, Agatha E. Ojimelukwe, Alba, Apisit Prakarnkamanant, BSG, Bayelsa State Governement, Centre for Food Security and Public Health CFSPH, De Benedictis, Ekong, Ezeibe, Fasina, Fasina, Fusaro, Goutard, Gugong, Hadorn, Henning, Henning, Henning, IFAD, Joannis, Joannis, Jonathan Rushton, Martin, Molia, Monne, Musa, Musa, Obayelu, OIE, Oluwayelu, Ortiz, Otte, Saidu, Salman, Spradbrow, Van Kerkhove, WAHID. World Animal Health Information Database, WORLD BANK   +37 more
core   +2 more sources

The Incidence of Drug- and Herbal and Dietary Supplement-Induced Liver Injury: Preliminary Findings from Gastroenterologist-Based Surveillance in the Population of the State of Delaware

Drug Safety, 2017
Maricruz Vega, M. Verma, D. Beswick, Stephanie Bey, Jared Hossack, Nathan Merriman, Ashish Shah, V. Navarro, for the Alberta Kidney Disease Network   +8 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Resurgence of scarlet fever in England, 2014-16: a population-based surveillance study.

Lancet. Infectious Diseases (Print), 2017
T. Lamagni, R. Guy, M. Chand, Katherine L Henderson, V. Chalker, James Lewis, V. Saliba, A. Elliot, Gillian E. Smith, S. Rushton, E. Sheridan, M. Ramsay, Alan P. Johnson   +12 more
semanticscholar   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Population surveillance of navigation frequency and palliative care contact before death among cancer patients. [PDF]

Can Oncol Nurs J, 2019
Johnston GM, Park G, Urquhart R, Walsh G, McCallum M, Rigby K.   +5 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Estimating age-stratified influenza-associated invasive pneumococcal disease in England: A time-series model based on population surveillance data. [PDF]

PLoS Med, 2019
Chiavenna C, Presanis AM, Charlett A, de Lusignan S, Ladhani S, Pebody RG, De Angelis D.   +6 more
europepmc   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source