Results 51 to 60 of about 536,545 (247)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Reported Adverse Events Following SARS-CoV-2 Vaccinations in the Canadian Province of Alberta and Associated Risk Factors: A Retrospective Cohort Study

Vaccines
Background/objectives: Coronavirus-19 (COVID-19) vaccines represent a significant milestone in the fight against coronavirus disease. Ongoing post-marketing surveillance and research are crucial for ensuring vaccine safety and effectiveness, aiding ...
Yei Mansou, Mahalakshmi Kumaran, Gregory Farmer, Kyle Kemp, Hussain Usman, David Strong, George K. Mutwiri, Khokan C. Sikdar   +7 more
doaj   +1 more source

Enhanced Surveillance of COVID-19 in Scotland - Population-based seroprevalence surveillance 13 October 2021 [PDF]

, 2021
Public Health Scotland
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Concordance of coverage estimates from routine and survey data of measles second dose vaccine in Western Kenya

Frontiers in Epidemiology
BackgroundMissed opportunities for key vaccinations continue to exacerbate disease outbreaks. Accurately monitoring immunisation coverage is fundamental to identifying gaps in vaccine delivery and informing timely action.
Angela K. Moturi, Angela K. Moturi, Moses M. Musau, Moses M. Musau, Moses M. Musau, Samuel K. Muchiri, Peter M. Macharia, Peter M. Macharia, Robert W. Snow, Robert W. Snow, Emelda A. Okiro, Emelda A. Okiro   +11 more
doaj   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Assessing the impact of COVID-19 pandemic on all-cause mortality and child mortality in a population cohort of Iganga Mayuge HDSS in Eastern Uganda (2015–2021)

Population Health Metrics
Background Efforts to track the mortality and public health impact of the coronavirus disease (COVID-19) in Uganda have been hampered by weak Civil registration and vital statistics (CRVS) system and suboptimal health seeking behaviors or patterns ...
Dan Kajungu, Betty Nabukeera, Jean Bashingwa, Chodziwadziwa Kabudula, Beth. T. Barr, Donald Ndyomugyenyi, Akello Mercy Consolate, Collins Gyezaho, Elizeus Rutebemberwa   +8 more
doaj   +1 more source

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source