Results 51 to 60 of about 36,617 (241)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Detection of viral agents associated with Porcine Respiratory Disease Complex (PRDC) in pigs in North Kerala

Journal of Veterinary and Animal Sciences
In pigs, stress factors such as pathogenic infections, environmental conditions, and various managemental practices can lead to a disease condition known as Porcine respiratory disease complex (PRDC).
Jayanth Kolar Venkatachalapathi, Shashank Somashekara, Rajasekhar Ravindran, Ajith Jacob George, Sumod Kanjirakkuzhiyil, Madhanraj Nallusamy, Sri Ramya Lakamana, Koshy John   +7 more
doaj   +1 more source

Mycoplasma suis infection in suckling pigs on a Belgian farm [PDF]

, 2008
Mycoplasma suis (formerly known as Eperythrozoon suis) is an epicellular bacterium that affects porcine red blood cells. M. suis infections occur worldwide and are associated with weakness and anemia in suckling and weaned pigs, and reproductive ...
De Busser, Emily Valerie, Haesebrouck, Freddy, Hoelzle, LE, Maes, Dominiek, Mateusen, Bart, Vicca, Jo   +5 more
core   +1 more source

Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate [PDF]

, 2010
Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is divided into a European and North American genotype. East European PRRSV isolates have been found to be of the European genotype, but form different subtypes. In the present study,
Geldhof, Marc, Karniychuk, Uladzimir, Nauwynck, Hans, Saveleva, TA, Van Doorsselaere, J, Vanhee, Merijn   +5 more
core   +2 more sources

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Pathogenicity Studies of NADC34-like Porcine Reproductive and Respiratory Syndrome Virus LNSY-GY and NADC30-like Porcine Reproductive and Respiratory Syndrome Virus GXGG-8011 in Piglets

Viruses, 2023
The porcine reproductive and respiratory syndrome virus (PRRSV) has caused significant economic losses to the swine industry. The U.S., China, and Peru have reported NADC30-like or NADC34-like PRRSV-infected piglets, which have been identified as the ...
Hechao Zhu, Liuqing Wei, Xiangzu Liu, Shudan Liu, Huanchun Chen, Pin Chen, Xiangmin Li, Ping Qian   +7 more
doaj   +1 more source

Serosurvey for viruses associated with reproductive failure in newly introduced gilts and in multiparous sows in Belgian sow herds [PDF]

, 2009
A serosurvey for viruses associated with reproductive disorders was conducted in 25 conventional Belgian farms. Serum antibody titers for porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus type 2 (PCV2), porcine parvovirus ...
Laitat, M, Lefebvre, David, Maes, Dominiek, Nauwynck, Hans, Van Driessche, E, Van Reeth, Kristien, Vangroenweghe, Frédéric   +6 more
core   +1 more source

Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage

Journal of General Virology, 2010
Porcine reproductive and respiratory syndrome virus (PRRSV) emerged in the late 1980s and rapidly became one of the most significant viral pathogens in the swine industry. In vivo, the virus shows a very narrow cell tropism and targets specific subsets of porcine macrophages.
Wander, Van Breedam, Peter L, Delputte, Hanne, Van Gorp, Gerald, Misinzo, Nathalie, Vanderheijden, Xiaobo, Duan, Hans J, Nauwynck   +6 more
openaire   +2 more sources

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Optimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]

, 2011
Peer reviewedPublisher ...
Campbell, Fiona Margaret, Carpintero, Rakel, Eckersall, P. David, Gruys, Erik, Heegaard, Peter M. H., Lampreave, Fermin, Piñeiro, Matilde, Skall Sorensen, Nanna, Stockmarr, Anders, Toussaint, Mathilda J.M.   +9 more
core   +4 more sources