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Cooperative Assembly of -Barrel Pore-Forming Toxins
Journal of Biochemistry, 2004Bacterial beta-barrel pore-forming toxins are secreted as water-soluble monomeric proteins and assemble into beta-barrel-shaped pores/channels through membranes of target cells, causing cell death and lysis. The pore assemblies that undergo various intermediate stages are symbolized by the association of multi-subunit structures in cells.
Vananh T, Nguyen, Yoshiyuki, Kamio
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Pore-forming Peptides and Protein Toxins
2003PART 1 PORE-FORMING PROTEINS Staphylococcal Bicomponent Leucotoxins, Mechanisms of Action, Impact on Cells and Contribution to Virulence, Gilles Prevost, Gianfranco Menestrina, Didier A. Colin, Sandra Werner, Stephen Bronner, Mauro Dalla Serra, Lamin Baba Moussa, Manual Coraiola, Alain Gravet, and Henri Monteil The Formulation of Ion-permeable Channels
G Menestrina +2 more
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Architecture of the pore forming toxin sticholysin I in membranes
Journal of Structural Biology, 2019Sticholysin I (StI) is a toxin produced by the sea anemone Stichodactyla helianthus and belonging to the actinoporins family. Upon binding to sphingomyelin-containing membranes StI forms oligomeric pores, thereby leading to cell death. According to recent controversial experimental evidences, the pore architecture of actinoporins is a debated topic ...
Yadira P, Hervis +8 more
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The Sensing of Membrane Microdomains Based on Pore-Forming Toxins
Current Medicinal Chemistry, 2013Membrane rafts are transient and unstable membrane microdomains that are enriched in sphingolipids, cholesterol, and specific proteins. They are involved in intracellular trafficking, signal transduction, pathogen entry, and attachment of various ligands.
M, Skočaj +5 more
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The Family of Serratia Type Pore Forming Toxins
Current Protein & Peptide Science, 2005The Serratia marcescens hemolysin represents the prototype of a growing family of pore forming toxins. The available bacterial genome sequences reveal Serratia hemolysin homologues in additional species. However, only S. marcescens hemolysin has been studied in great molecular detail.
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Pore-forming toxins from pathogenic amoebae
Applied Microbiology and Biotechnology, 2014Some amoeboid protozoans are facultative or obligate parasites in humans and bear an enormous cytotoxic potential that can result in severe destruction of host tissues and fatal diseases. Pathogenic amoebae produce soluble pore-forming polypeptides that bind to prokaryotic and eukaryotic target cell membranes and generate pores upon insertion and ...
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Pore-Forming Bacterial Protein Toxins: An Overview
2001Among the ca. 325 protein toxins produced by gram-positive and gram-negative bacteria so far identified (Alouf 2000), at least 115 (35%) belong to the group of the so-called membrane-damaging toxins (MDTs). The most characteristic feature of these effectors is to damage or disrupt the cytoplasmic phospholipid bilayer membrane (7–9nm) of appropriate ...
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Emerging Enterococcus Pore-Forming Toxins With MHC/HLA-I as Receptors
Cell, 2022Jianbin Ruan +2 more
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Pore-Forming Toxins: Ancient, but Never Really Out of Fashion
Nature Reviews Microbiology, 2016Matteo Dal Peraro +2 more
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