Structural Basis of the Pore-Forming Toxin/Membrane Interaction [PDF]
Toxins, 2021 With the rapid growth of antibiotic-resistant bacteria, it is urgent to develop alternative therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence factors of many pathogenic bacteria and constitute the most ...
Yajuan Li +9 more
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Curcumin Inhibits Membrane-Damaging Pore-Forming Function of the β-Barrel Pore-Forming Toxin Vibrio cholerae Cytolysin [PDF]
Frontiers in Microbiology, 2022 Vibrio cholerae cytolysin (VCC) is a β-barrel pore-forming toxin (β-PFT). Upon encountering the target cells, VCC forms heptameric β-barrel pores and permeabilizes the cell membranes.
Mahendra Singh +3 more
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Temporary Membrane Permeabilization via the Pore-Forming Toxin Lysenin [PDF]
Toxins, 2020 Pore-forming toxins are alluring tools for delivering biologically-active, impermeable cargoes to intracellular environments by introducing large conductance pathways into cell membranes.
Nisha Shrestha +8 more
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Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB [PDF]
Nature Communications, 2018 The Yersinia YaxAB system is a pore-forming toxin of so far unknown structure. Here authors present X-ray and cryo-EM to structures of individual subunits and of the YaxAB pore complex, and find that YaxA binds to membranes first and recruits YaxB for ...
Bastian Bräuning +9 more
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Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins [PDF]
Nature CommunicationsABC toxins are toxin-translocating, pore-forming proteins found in a wide range of insecticidal bacteria and some mammalian pathogens. The Yersinia entomopahaga toxin complex (YenTc) belongs to a distinct subclass of ABC toxins, defined by a divergent ...
Yu Shang Low +13 more
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Alciporin, a pore-forming protein as complementary defense mechanism in Millepora alcicornis
Frontiers in Marine Science, 2022 Millepora alcicornis (Cnidaria: Hydrozoa), known as fire coral, is a tropical species settled in marine ecosystems of the Canary Islands in the last years.
Nathalia Nocchi +13 more
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Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum. [PDF]
PLoS Pathogens, 2009 Programmed necrosis is a mechanism of cell death that has been described for neuronal excitotoxicity and ischemia/reperfusion injury, but has not been extensively studied in the context of exposure to bacterial exotoxins.
Catherine L Kennedy +4 more
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Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin. [PDF]
PLoS ONE, 2015 The plethora of virulence factors associated with Staphylococcus aureus make this bacterium an attractive candidate for a molecularly-designed epitope-focused vaccine.
Jon Oscherwitz, Kemp B Cease
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The pore structure of Clostridium perfringens epsilon toxin
Nature Communications, 2019 Epsilon toxin (Etx) is a potent pore forming toxin (PFT) produced by Clostridium perfringens. Here authors show the cryo-EM structure of the Etx pore assembled on the membrane of susceptible cells and shed light on pore formation and mutant phenotypes.
Christos G. Savva +7 more
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Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
Toxins, 2019 Pore-forming toxins (PFTs) form nanoscale pores across target membranes causing cell death. The pore-forming cytolysins of the RTX (repeats in toxin) family belong to a steadily increasing family of proteins characterized by having in their primary ...
Helena Ostolaza +5 more
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