Results 141 to 150 of about 32,945 (258)

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients with Extra‐Renal Systemic Lupus Erythematosus – A Systematic Review & Meta‐analysis

Arthritis Care &Research, Accepted Article.
Background Clinical response to Mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with SLE, particularly those with extra‐renal ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Insights into the Protein-Lipid Interaction of Perivitellin-2, an Unusual Snail Pore-Forming Toxin. [PDF]

Toxins (Basel)
Vázquez RF, Daza Millone MA, Giglio ML, Brola TR, Maté SM, Heras H.   +5 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Single-Chain Nanobody Inhibition of Notch and Avidity Enhancement Utilizing the β-Pore-Forming Toxin Aerolysin. [PDF]

ACS Chem Biol
Lemmex ACD, Allred J, Ostergard J, Trask J, Bui HN, Anderson MJM, Kopp B, Streeter O, Smiley AT, Babilonia-Díaz NS, Blazar BR, Higgins L, Gordon PM, Muretta JM, Gordon WR.   +14 more
europepmc   +1 more source

Compressible Flow Exfoliation of Two‐Dimensional Nanomaterials: Insights Into Layer Separation Informed by Gas Dynamics

Advanced Engineering Materials, EarlyView.
This study elucidates the mechanism of compressible flow exfoliation for producing 2D hexagonal boron nitride (h‐BN). Fluid dynamics analysis reveals that acceleration‐driven aerodynamic shear forces, rather than shock waves alone, drive effective layer separation.
Md Farhadul Islam, Saeed Arabha, Ray Hixon, Reza Rizvi   +3 more
wiley   +1 more source

Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila. [PDF]

J Innate Immun
Magyar LB, Ábrahám E, Lipinszki Z, Tarnopol RL, Whiteman NK, Varga V, Hultmark D, Andó I, Cinege G.   +8 more
europepmc   +1 more source

The A component (SmhA) of a tripartite pore-forming toxin from Serratia marcescens: expression, purification and crystallographic analysis. [PDF]

Acta Crystallogr F Struct Biol Commun, 2020
Churchill-Angus AM, Sedelnikova SE, Schofield THB, Baker PJ.   +3 more
europepmc   +1 more source

Enhanced Gamma Radiation Shielding Using Epoxy Quartz Fabric Composites Reinforced With CoCl2 Microparticles

Advanced Engineering Materials, EarlyView.
The growing demand for lightweight, nontoxic, and multifunctional gamma shielding materials has intensified efforts to find alternatives to conventional lead and aluminum‐based protectants. In this work, we develop epoxy quartz fabric composites reinforced with cobalt chloride (CoCl2) microparticles, fabricated via hand lay‐up with varying filler ...
Summan Urooge, Ahsan Irshad, Umar Jamil, Srosh Fazil, Khuram Liaqat, Kashif Shahzad, Fakhar Alam, Mehboob Alam   +7 more
wiley   +1 more source

The Helix Ring Peptide U11 from the Venom of the Ant, Tetramorium bicarinatum, Acts as a Putative Pore-Forming Toxin, Not a New Kv1.3 Channel Blocker. Comment on Boy et al. A New Kv1.3 Channel Blocker from the Venom of the Ant Tetramorium bicarinatum. Toxins 2025, 17, 379. [PDF]

Toxins (Basel)
Peigneur S, Tibery D, Tytgat J.
europepmc   +1 more source

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. [PDF]

PLoS Pathog, 2020
Badgujar DC, Anil A, Green AE, Surve MV, Madhavan S, Beckett A, Prior IA, Godsora BK, Patil SB, More PK, Sarkar SG, Mitchell A, Banerjee R, Phale PS, Mitchell TJ, Neill DR, Bhaumik P, Banerjee A.   +17 more
europepmc   +1 more source