Results 11 to 20 of about 32,945 (258)
Bacterial pore-forming toxins.
Microbiology (Reading, England), 2022 Pore-forming toxins (PFTs) are widely distributed in both Gram-negative and Gram-positive bacteria. PFTs can act as virulence factors that bacteria utilise in dissemination and host colonisation or, alternatively, they can be employed to compete with rival microbes in polymicrobial niches. PFTs transition from a soluble form to become membrane-embedded
Ulhuq, Fatima R., Mariano, Giuseppina
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Pore‐forming toxins of foodborne pathogens [PDF]
Comprehensive Reviews in Food Science and Food Safety, 2021 Abstract Pore‐forming toxins (PFTs) are water‐soluble molecules that have been identified as the most crucial virulence factors during bacterial pathogenesis. PFTs disrupt the host cell membrane to internalize or to deliver other bacterial or virulence factors for establishing infections.
Rajashri Banerji +3 more
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Membrane perforation by the pore-forming toxin pneumolysin. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Pneumolysin, a pore-forming toxin of Streptococcus pneumoniae , assembles into rings on cholesterol-containing membranes of host cells. β -hairpins form a barrel-shaped transmembrane
Vögele M +7 more
europepmc +7 more sources
Enhanced SnapShot: Pore-Forming Toxins [PDF]
Cell, 2010 Enhanced SnapShots include features only possible online—animations, embedded captions, and dynamic visuals—all accessible by the click of a mouse. The goal of an Enhanced SnapShot is to provide everything currently available with the print SnapShot plus additional layers of information that are accessible through an easy to navigate interface.The ...
Mueller, Marcus, Ban, Nenad
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Pore-Forming Toxins Trigger the Purge [PDF]
Cell Host & Microbe, 2016 The intestinal epithelium responds to pathogens by coordinating microbial elimination with tissue repair, both required to survive an infection. In this issue of Cell Host & Microbe, Lee et al. (2016) discover a rapid and evolutionarily conserved response to pore-forming toxins in the gut, involving cytoplasm ejection and enterocyte regrowth.
Alessandro, Bonfini, Nicolas, Buchon
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Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins [PDF]
Frontiers in Immunology, 2022 Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis.
Thomas J. R. Ormsby +6 more
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Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane
Nature Communications, 2021 The Vip3 family proteins from Bacillus thuringiensis are thought to exert their insecticidal activity through pore formation. Here authors present cryo-EM structures of a Vip3 family toxin in both inactive and activated forms and show the activated ...
Matthew J. Byrne +9 more
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Repair of a Bacterial Small β-Barrel Toxin Pore Depends on Channel Width
mBio, 2017 Membrane repair emerges as an innate defense protecting target cells against bacterial pore-forming toxins. Here, we report the first paradigm of Ca2+-dependent repair following attack by a small β-pore-forming toxin, namely, plasmid-encoded phobalysin ...
Gisela von Hoven +7 more
doaj +1 more source
mBio, 2017 Modular bacteriocins represent a major group of secreted protein toxins with a narrow spectrum of activity, involved in interference competition between Gram-negative bacteria.
Maarten G. K. Ghequire +4 more
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Structural Insights into Clostridium perfringens Delta Toxin Pore Formation.
PLoS ONE, 2013 Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
Jessica Huyet +5 more
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