Results 21 to 30 of about 32,945 (258)
The Ionic Selectivity of Lysenin Channels in Open and Sub-Conducting States
Membranes, 2021 The electrochemical gradients established across cell membranes are paramount for the execution of biological functions. Besides ion channels, other transporters, such as exogenous pore-forming toxins, may present ionic selectivity upon reconstitution in
Andrew Bogard +6 more
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Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
Toxins, 2018 Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis.
Asier Etxaniz +3 more
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Pore Forming Protein Induced Biomembrane Reorganization and Dynamics: A Focused Review
Frontiers in Molecular Biosciences, 2021 Pore forming proteins are a broad class of pathogenic proteins secreted by organisms as virulence factors due to their ability to form pores on the target cell membrane.
Ilanila Ilangumaran Ponmalar +4 more
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Inhibition of Pore-Forming Proteins
Toxins, 2019 Perforation of cellular membranes by pore-forming proteins can affect cell physiology, tissue integrity, or immune response. Since many pore-forming proteins are toxins or highly potent virulence factors, they represent an attractive target for the ...
Neža Omersa +2 more
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DEFENSE AND DEATH RESPONSES TO PORE FORMING TOXINS [PDF]
Biotechnology and Genetic Engineering Reviews, 2009 Pore forming toxins (PFT) are important virulence factors produced by bacteria to kill eukaryotic cells by forming holes in the cellular membrane. They represent a diverse group of proteins with a wide range of target cells. Although the amino acid sequence is not conserved among the different PFT, many of them share some aspects of their mechanism of ...
Angeles, Cancino-Rodezno +3 more
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The Ins and Outs of Anthrax Toxin
Toxins, 2016 Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic ...
Sarah Friebe +2 more
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Recent Insights into Clostridium perfringens Beta-Toxin
Toxins, 2015 Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect.
Masahiro Nagahama +5 more
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Cellular and Molecular Life Sciences, 2002 Pore-forming toxins are widely distributed proteins which form lesions in biological membranes. In this review, bacterial pore-forming toxins are treated as a paradigm and discussed in terms of the structural principles on which they work. Then, a large family of bacterial toxins, the cholesterol-binding toxins, are analyzed in depth to provide an ...
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Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process
Nature Communications, 2016 Aerolysin is a secreted bacterial pore forming toxin that inserts into the host plasma membrane, potentially leading to cell death. Here the authors present Cryo-EM structures of aerolysin arrested at different stages of the pore formation process that ...
Ioan Iacovache +5 more
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Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin
PathogensClostridium perfringens alpha toxin (CPA), which causes yellow lamb disease in sheep and gas gangrene and food poisoning in humans, is produced by all types of C. perfringens and is the major virulence determinant of C. perfringens type A.
Zishuo Guo +14 more
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