Results 41 to 50 of about 32,945 (258)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

c-Jun Proto-Oncoprotein Plays a Protective Role in Lung Epithelial Cells Exposed to Staphylococcal α-Toxin

Frontiers in Cellular and Infection Microbiology, 2018
c-Jun is a member of the early mammalian transcriptional regulators belonging to the AP-1 family, which participates in a wide range of cellular processes such as proliferation, apoptosis, tumorigenesis, and differentiation.
Alejandro J. Moyano, Alejandro J. Moyano, Ana C. Racca, Ana C. Racca, Gastón Soria, Gastón Soria, Héctor A. Saka, Héctor A. Saka, Verónica Andreoli, Verónica Andreoli, Andrea M. Smania, Andrea M. Smania, Claudia Sola, Claudia Sola, José L. Bocco, José L. Bocco   +15 more
doaj   +1 more source

Resurfacing receptor binding domain of Colicin N to enhance its cytotoxic effect on human lung cancer cells

Computational and Structural Biotechnology Journal, 2021
Colicin N (ColN) is a bacteriocin secreted by Escherichia coli (E. coli) to kill other Gram-negative bacteria by forcefully generating ion channels in the inner membrane.
Wanatchaporn Arunmanee, Methawee Duangkaew, Pornchanok Taweecheep, Kanokpol Aphicho, Panuwat Lerdvorasap, Jesada Pitchayakorn, Chayada Intasuk, Runglada Jiraratmetacon, Armini Syamsidi, Pithi Chanvorachote, Chatchai Chaotham, Natapol Pornputtapong   +11 more
doaj   +1 more source

Host glycan recognition by a pore forming toxin. [PDF]

Structure, 2012
An exposed F-type lectin domain fused to the N-terminus of a cholesterol-dependent cytolysin scaffold allows Streptococcus mitis lectinolysin to cluster at fucose-rich sites on target cell membranes, thereby leading to increased pore-forming toxin activity.
Bouyain S, Geisbrecht BV.
europepmc   +4 more sources

Pore-forming activity of clostridial binary toxins

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016
Clostridial binary toxins (Clostridium perfringens Iota toxin, Clostridium difficile transferase, Clostridium spiroforme toxin, Clostridium botulinum C2 toxin) as Bacillus binary toxins, including Bacillus anthracis toxins consist of two independent proteins, one being the binding component which mediates the internalization into cell of the ...
Knapp, O., Benz, R., Popoff, Michel Robert   +2 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Serine clamp of Clostridium perfringens binary toxin BECb (CPILEb)-pore confers cytotoxicity and enterotoxicity

Communications Biology
BEC (CPILE) is a virulence factor of the pathogen, Clostridium perfringens, which has caused foodborne outbreaks in Japan. BEC is a binary toxin that comprises the enzymatic A-component (BECa) and the B-component (BECb); the latter forms a membrane pore ...
Toru Yoshida, Chie Monma, Yuki Ninomiya, Sotaro Takiguchi, Shoko Fujita, Yuto Uchida, Noriaki Sakoda, Vladimir A. Karginov, Jun-ichi Kishikawa, Tomohito Yamada, Ryuji Kawano, Hideaki Tsuge   +11 more
doaj   +1 more source

Cytotoxic Effect of Recombinant Fragaceatoxin C on Peripheral Blood Mononuclear Cells [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objectives: Actinoporins from sea anemones are potent pore-forming toxins. Fragaceatoxin C belongs to this family with a molecular weight of 20 kDa that mainly binds sphingomyelin in membranes and forming 2nm in diameter cation-selective ...
Leyla Darbarfard, Mehdi Imani, Seyyed Meysam Abtahi Froushani   +2 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Exolysin Shapes the Virulence of Pseudomonas aeruginosa Clonal Outliers

Toxins, 2017
Bacterial toxins are important weapons of toxicogenic pathogens. Depending on their origin, structure and targets, they show diverse mechanisms of action and effects on eukaryotic cells.
Emeline Reboud, Pauline Basso, Antoine P. Maillard, Philippe Huber, Ina Attrée   +4 more
doaj   +1 more source