Results 51 to 60 of about 32,945 (258)

The MACPF/CDC family of pore-forming toxins [PDF]

Cellular Microbiology, 2008
Pore-forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In eukaryotes, however, PFTs operate in the immune system or are deployed for attacking prey (e.g. venoms). This review focuses upon two families of globular protein PFTs: the cholesterol-dependent cytolysins (CDCs) and the membrane attack complex/perforin superfamily ...
Rosado, CJ, Kondos, S, Bull, TE, Kuiper, MJ, Law, RHP, Buckle, AM, Voskoboinik, I, Bird, PI, Trapani, JA, Whisstock, JC, Dunstone, MA   +10 more
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Prevalence of Clostridium perfringens netE and netF toxin genes in the feces of dogs with acute hemorrhagic diarrhea syndrome

Journal of Veterinary Internal Medicine, 2019
Background Recently, novel pore‐forming toxin genes designated netE and netF were identified in a Clostridium perfringens type A strain isolated from a dog with acute hemorrhagic diarrhea.
Natalie Sindern, Jan S. Suchodolski, Christian M. Leutenegger, Iman Mehdizadeh Gohari, John F. Prescott, Anna‐Lena Proksch, Ralf S. Mueller, Kathrin Busch, Stefan Unterer   +8 more
doaj   +1 more source

The Pore-Forming Haemolysins of Bacillus Cereus: A Review

Toxins, 2013
The Bacillus cereus sensu lato group contains diverse Gram-positive spore-forming bacteria that can cause gastrointestinal diseases and severe eye infections in humans. They have also been incriminated in a multitude of other severe, and frequently fatal,
Vincent Sanchis, Nalini Ramarao
doaj   +1 more source

Role of Pore-Forming Toxins in Neonatal Sepsis [PDF]

Clinical and Developmental Immunology, 2013
Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci,Escherichia coli,Listeria monocytogenes, andStaphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease.
Andreas F.-P. Sonnen, Philipp Henneke
openaire   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Identification of a Key Residue for Oligomerisation and Pore-Formation of Clostridium perfringens NetB

Toxins, 2014
Necrotic enteritis toxin B (NetB) is a β-pore-forming toxin produced by Clostridium perfringens and has been identified as a key virulence factor in the pathogenesis of avian necrotic enteritis, a disease causing significant economic damage to the ...
Sérgio P. Fernandes da Costa, Christos G. Savva, Monika Bokori-Brown, Claire E. Naylor, David S. Moss, Ajit K. Basak, Richard W. Titball   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cloning and Characterization of a Unique Cytotoxic Protein Parasporin-5 Produced by Bacillus thuringiensis A1100 Strain

Toxins, 2014
Parasporin is the cytocidal protein present in the parasporal inclusion of the non-insecticidal Bacillus thuringiensis strains, which has no hemolytic activity but has cytocidal activities, preferentially killing cancer cells.
Keisuke Ekino, Shiro Okumura, Tomoyuki Ishikawa, Sakae Kitada, Hiroyuki Saitoh, Tetsuyuki Akao, Takuji Oka, Yoshiyuki Nomura, Michio Ohba, Takashi Shin, Eiichi Mizuki   +10 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source