Results 61 to 70 of about 8,129,869 (250)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Pore Network Modeling of Multiphase Transport in Polymer Electrolyte Membrane Fuel Cell Gas Diffusion Layers [PDF]

, 2015
In this thesis, pore network modeling was used to study how the microstructure of the polymer electrolyte membrane (PEM) fuel cell gas diffusion layer (GDL) influences multiphase transport within the composite layer.
Fazeli, Mohammadreza
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Computational and experimental pore-scale studies of a carbonate rock sample

Journal of Hydrology and Hydromechanics, 2019
Carbonate rocks host several large water and hydrocarbon reservoirs worldwide, some of them highly heterogeneous involving complex pore systems. Pre-salt reservoirs in the Santos Basin off the south-east coast of Brazil, are an example of such rocks ...
Godoy William, Pontedeiro Elizabeth M., Hoerlle Fernanda, Raoof Amir, van Genuchten Martinus Th., Santiago José, Couto Paulo   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Pore-Scale Effect of Dissolution on Residual Oil Saturation in Carbonate Rock Under Three Wettability Conditions

Applied Sciences
Dissolution increases the porosity and permeability of carbonate rock, but its effect on residual oil saturation and the dependence of this effect on wettability remain poorly constrained. This work evaluates how dissolution-induced changes in pore space
Darezhat Bolysbek, Kenbay Uzbekaliyev, Bakytzhan Assilbekov, Alibek Kuljabekov, Zhibek Akasheva   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Determinação de propriedades petrofísicas de rochas reservatórios usando modelos de redes de poros [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-graduação em Ciências e Engenharia de Materiais, Florianópolis, 2014A pesquisa na área de produção de petróleo tem como principal objetivo otimizar a ...
Kronbauer, Denise Prado
core  

Image-Based Pore-Scale Modeling of Inertial Flow in Porous Media and Propped Fractures [PDF]

, 2014
Non-Darcy flow is often observed near wellbores and in hydraulic fractures where relatively high velocities occur. Quantifying additional pressure drop caused by non-Darcy flow and fundamentally understanding the pore-scale inertial flow is important to ...
Shen, Yijie, Yijie Shen, null null
core   +1 more source