Results 231 to 240 of about 912,769 (306)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Toward Pore Size-Selective Photoredox Catalysis Using Bifunctional Microporous 2D Triazine-Based Covalent Organic Frameworks. [PDF]

ACS Omega
Kenari ME, Maiti S, Ling J, El-Shamy X, Bagga H, Addicoat MA, Milner PJ, Das A.   +7 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evaluating the effect of pore size for 3d-printed bone scaffolds. [PDF]

Heliyon
Seehanam S, Khrueaduangkham S, Sinthuvanich C, Sae-Ueng U, Srimaneepong V, Promoppatum P.   +5 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Pore Size Distribution and Fractal Characteristics of Deep Coal in the Daning-Jixian Block on the Eastern Margin of the Ordos Basin. [PDF]

ACS Omega
Zhang B, Wang H, Sun B, Ouyang Z, Dou W, Wang B, Lai P, Hu Z, Luo B, Yang M, Zeng Z.   +10 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Heterogeneous Viscosity Flow Model for Liquid Transport through Nanopores Considering Pore Size and Wettability. [PDF]

Molecules
Chang Y, Zhang Y, Niu Z, Chen X, Du M, Yang Z.   +5 more
europepmc   +1 more source

High-Energy Density Pure Polyvinylidene Difluoride with the Magnetic Field Modulation of Free-Volume Pore Size and Other Microstructures. [PDF]

Polymers (Basel)
Liu Z, Qiao J, Liu C, Qiao S.
europepmc   +1 more source

Tuning Pore Size in Graphene in the Angstrom Regime for Highly Selective Ion-Ion Separation. [PDF]

ACS Nano
Zhao K, Lee WC, Rezaei M, Chi HY, Li S, Villalobos LF, Hsu KJ, Zhang Y, Wang FC, Agrawal KV.   +9 more
europepmc   +1 more source