Results 111 to 120 of about 7,829,285 (311)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Role of Material Structure in Compacted Earthen Building Materials: Implications for Design and Construction [PDF]
, 2011 Rammed earth is an earthen construction material and an ancient construction technique. It is formed by compacting layers of moist sandy loam subsoil into formwork which is then removed, exposing the material and creating a freestanding, monolithic ...
BECKETT, CHRISTOPHER,THOMAS,STONE +1 more
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Pore-scale simulation of NMR response
, 2009 The random walk method is used to simulate magnetization decay in porous media. The simulations were performed on images of the pore space obtained using micro-CT scanning and in topologically equivalent networks extracted from these images using a ...
O. Talabi (23304247) +3 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure and Characteristics of Spherical-Pore Silicon Carbide
, 2011 Sintered Silicon Carbide material with fine grain structure shows excellent wear resistance, highly chemically resistance, excellent performance in a wide range of applications.
Jin Feng Xia +5 more
core +1 more source
Youqicang pingjia yu kaifa, 2021 In order to study the evaluation standard of deep shale reservoirs,their micro pore characteristics have been studied.Based on the ideas of micro pore structure research with "high precision and cross scale",and by using nitrogen adsorption,high pressure
XIONG Liang +5 more
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source