Clinical, biochemical, and genetic characterization of acute hepatic porphyrias in a cohort of Argentine patients [PDF]
Molecular Genetics & Genomic Medicine, 2021 Background Acute Hepatic Porphyrias (AHPs) are characterized by an acute neuroabdominal syndrome including both neuropsychiatric symptoms and neurodegenerative changes.
María del Carmen Martinez +5 more
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Acute Intermittent Porphyria in a Man with Dual Enzyme Deficiencies [PDF]
Case Reports in Genetics, 2020 Porphyrias are a heterogeneous group of metabolic disorders that result from the altered activity of specific enzymes of the heme biosynthetic pathway and are characterized by accumulation of pathway intermediates.
G. N. Cerbino +6 more
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An Improved Technique for Genotyping the ABCB1 Gene Variant of Exon 21 [PDF]
Methods and Protocols, 2023 The Multidrug Resistance protein (ABCB1, MDR1) is involved in the transport of xenobiotics and antiretroviral drugs. Some variants of the ABCB1 gene are of clinical importance; among them, exon 12 (c.1236C>T, rs1128503), 21 (c.2677G>T/A, rs2032582), and ...
Johanna Romina Zuccoli +5 more
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An increase in O-GlcNAcylation of Sp1 down-regulates the gene expression of pi class glutathione S-transferase in diabetic mice [PDF]
Biochemistry and Biophysics Reports, 2021 Oxidative stress is a key factor contributing to the development of diabetes complications. Glutathione S-transferases (GSTs) protect against products of oxidative stress by conjugating glutathione to electrophilic substrates, producing compounds that ...
Leda María Oliveri +2 more
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Photosensitization of a subcutaneous tumour by the natural anthraquinone parietin and blue light [PDF]
Scientific Reports, 2021 Photodynamic therapy (PDT) is an anticancer treatment involving administration of a tumour-localizing photosensitizer, followed by activation by light of a suitable wavelength. In previous work, we showed that the natural anthraquinone (AQ) Parietin (PTN)
María Laura Mugas +9 more
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Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer [PDF]
BMC Cancer, 2021 Background Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species.
Pablo Vallecorsa +8 more
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The Impact of Low-Level Benzalkonium Chloride Exposure on Staphylococcus spp. Strains and Control by Photoinactivation [PDF]
Antibiotics, 2023 Exposure of bacteria to low concentrations of biocides can facilitate horizontal gene transfer, which may lead to bacterial adaptive responses and resistance to antimicrobial agents.
Erika C. R. Bonsaglia +6 more
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Regulation of the expression of ferrochelatase in a murine model of diabetes mellitus type I [PDF]
Biochemistry and Biophysics ReportsBackground: Diabetes produces changes on cellular hemeprotein metabolism. The last enzyme of heme biosynthetic pathway is ferrochelatase (FECH), an enzyme that catalyzes the insertion of ferrous ion into protoporphyrin IX to produce heme. The aim of this
Leda María Oliveri +2 more
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Porfiria intermitente aguda: reporte de caso [PDF]
Biomédica: revista del Instituto Nacional de Salud, 2020 El término ‘porfiria’ proviene del griego ‘porphyra’ y alude a un grupo heterogéneo de trastornos metabólicos causados por una deficiencia enzimática en la biosíntesis del grupo hemo.
José Bustos +2 more
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Protective effect exerted by soil phosphorus on soybean subjected to arsenic and fluoride. [PDF]
Redox Rep, 2017 Objetive: Arsenic (As) and fluoride (F) are found in groundwater and soils around the world, causing different problems to crops. Because these elements compete against phosphorus (P) in soils and plants, their relationship is complex.
Bustingorri C +3 more
europepmc +3 more sources