Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin [PDF]
The Scientific World Journal, 2014 Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin.
M. del C. Martinez +3 more
doaj +3 more sources
Trypanocidal activity of thioamide-substituted imidazoquinolinone: electrochemical properties and biological effects. [PDF]
Evid Based Complement Alternat Med, 2013 Three thioamide-substituted imidazoisoquinolinones, which possess an heterocyclic center similar to tryptanthrin and are named C1, C2 and C3, were studied regarding: a) its in vitro anti-Trypanosoma cruzi activity, b) its cytotoxicity and ...
Frank FM +5 more
europepmc +7 more sources
International Journal of Photoenergy, 2014 Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during
Leandro Mamone +5 more
doaj +2 more sources
Fluorescent redox-dependent labeling of lipid droplets in cultured cells by reduced phenazine methosulfate [PDF]
Heliyon, 2020 Natural and synthetic phenazines are widely used in biomedical sciences. In dehydrogenase histochemistry, phenazine methosulfate (PMS) is applied as a redox reagent for coupling reduced coenzymes to the reduction of tetrazolium salts into colored ...
Juan C. Stockert +9 more
doaj +2 more sources
Delta-aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines. [PDF]
BMC Cancer, 2002 BACKGROUND: Acute Intermittent Porphyria is a genetic disorder of heme metabolism, characterized by increased levels of porphyrin precursors, delta-aminolevulinic acid (ALA) and porphobilinogen (PBG).
De Siervi A +4 more
europepmc +6 more sources
Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for Photodynamic Therapy [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2009 Photodynamic therapy (PDT) based on topical 5-aminolevulinic acid (5-ALA), an endogenous precursor of protoporphyrin, is an interesting approach for the treatment of skin cancer.
Maria Bernadete Riemma Pierre +2 more
doaj +5 more sources
Acute intermittent porphyria in Argentina: an update. [PDF]
Biomed Res Int, 2015 Porphyrias are a group of metabolic diseases that arise from deficiencies in the heme biosynthetic pathway. A partial deficiency in hydroxymethylbilane synthase (HMBS) produces a hepatic disorder named Acute Intermittent Porphyria (AIP); the acute porphyria is more frequent in Argentina.
Cerbino GN +6 more
europepmc +2 more sources
Experimental protoporphyria: effect of bile acids on liver damage induced by griseofulvin. [PDF]
Biomed Res Int, 2015 The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to diminish liver damage induced by Gris.
Martinez Mdel C +5 more
europepmc +2 more sources
Modulation of 5-Aminolevulinic acid mediated photodynamic therapy induced cell death in a human lung adenocarcinoma cell line [PDF]
, 2016 Photodynamic therapy (PDT) is a cancer treatment involving the administration of a photosensitising drug which selectively accumulates in tumor tissue, followed by irradiation with appropriate wavelength light.
Battle, A. +3 more
core +2 more sources
Photodynamic inactivation of planktonic and biofilm growing bacteria mediated by a meso-substituted porphyrin bearing four basic amino groups [PDF]
, 2016 Biofilm-associated diseases account for 80% of all infections in humans. Due to the emergence of antibiotic resistances, alternative therapies such as Photodynamic Inactivation (PDI) of microorganisms have emerged.
Batlle, Alcira María del C. +10 more
core +1 more source