Results 51 to 60 of about 257,215 (268)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Mechanical Behavior of Porous Ni-Ti Alloy Produced by Bulk Combustion Synthesis Method for Bone Surgery

open access: yesJournal of Advanced Materials in Engineering, 2015
Mechanical property of porous nickel-titanium alloy produced by volumetric combustion synthesis (VCS) for bone surgery applications is reported in this paper. Stress-strain behavior of the alloy is determined by uniaxial tension test.
sadrnezhad, S. Katiraei
doaj  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Chofu campus of the Toho Gakuen School of Music

open access: yesJapan Architectural Review, 2018
Project for a music school. Due to the superfluous consciousness of ambient noise and sound insulation, many music college facilities employ a style in which the exterior appears as a closed box and the lesson rooms are lined up along corridors in a jail‐
Tomohiko Yamanashi   +3 more
doaj   +1 more source

Computational analysis of inserted porous blocks into horizontal concentric annuli in mixed convecti

open access: yesJournal of Thermal Engineering, 2018
This study numerically investigates the effect of porous blocks thickness on laminar mixed convection in a horizontal annulus. With attached four porous blocks on the inner cylinder, steady 3D laminar mixed convection is presented for the fully developed
Yacine Ould-Amer
doaj   +1 more source

TRANSFERS IN POROUS MEDIA [PDF]

open access: yesSpecial Topics & Reviews in Porous Media: An International Journal, 2014
Modelling heat transfer in porous media requires to take into account multiple-scale aspects inherent to porous media structures. Several methodologies have been developed to upscale the equations at a lower-scale and to obtain upper-scale models as it is outlined in a brief review based on a simple heat conduction example proposed in the first part of
openaire   +4 more sources

Home - About - Disclaimer - Privacy