Results 91 to 100 of about 8,773 (221)
Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT mRNA encapsulated in lipid nanoparticles (LNPs) provides a dual revolution in the field of gene therapy. mRNA brings fleeting efficacy and the possibility to adjust the therapy to clinical needs. LNP, as a non‐viral vehicle with flexible organ‐targeting, overcomes most immune complications of viral gene therapy. mRNA‐LNP has rapidly progressed
Sonam Gurung +4 more
wiley +1 more source
Systematic identification of gene families for use as markers for phylogenetic and phylogeny- driven ecological studies of bacteria and archaea and their major subgroups [PDF]
, 2013 With the astonishing rate that the genomic and metagenomic sequence data sets are accumulating, there are many reasons to constrain the data analyses.
Eisen, Jonathan A. +2 more
core +4 more sources
A family with acute intermittent porphyria [PDF]
, 2008 Porphyrias are inherited defects in heme metabolism that result in excessive secretion of porphyrins and porphyrin precursors. Porphyrias can be classified into acute, (neuropsychiatric), cutaneous and mixed forms.
Billoo, Abdul Gaffar, Lone, Saira Waqar
core +1 more source
Liquid chromatography-tandem mass spectrometry - Application in the clinical laboratory [PDF]
, 2003 This review provides a concise survey of liquid chromatography tandem mass spectrometry (LCTMS) as an emerging technology in clinical chemistry. The combination of two mass spectrometers with an interposed collision cell characterizes LCTMS as an ...
Ford RE +7 more
core +1 more source
Acute Intermittent Porphyria: A Report of 3 Cases with Neuropathy
Case Reports in Neurology, 2019 The porphyrias are metabolic disorders due to a defect in the heme biosynthetic pathway. Patients have diverse clinical presentations with neuropathy being frequent in acute intermittent porphyria (AIP).
Mohammed Alqwaifly +2 more
doaj +1 more source
Safe use of perampanel in a carrier of variegate porphyria [PDF]
, 2016 Objectives. Treatment of chronic epilepsy in acute porphyrias may be difficult because many antiepileptic drugs can cause activation of clinically-latent conditions. Methods.
Balestrini, S +3 more
core +1 more source
Cell Transplantation, 2014 Acute intermittent porphyria (AIP) is an autosomal dominant disorder characterized by insufficient porphobilinogen deaminase (PBGD) activity. When hepatic heme synthesis is induced, porphobilinogen (PBG) and 5-aminolevulinic acid (ALA) accumulate, which ...
Zhaohui Yin +5 more
doaj +1 more source
BioTechniques, 1999 Analysis of gene expression and its transcriptional regulation requires a reliable access to target mRNA. However, mRNA extractions from homogenized tissue are limited because only average data are obtained, and cell-specific expression may not be ...
L. Fink +5 more
doaj +1 more source
PORPHOBILINOGEN IN LEAD POISONING
Sangyo Igaku, 1972 Lead poisoning is associated with characteristic urinary increases of δ-aminolevulinic acid and coproporphyrinogen III, elevated erythrocyte protoporphyrin concentration and partial block of δ- aminolevulinic acid dehydratase.In human lead poisoning a very small amount of increase of porphobilinogen and uroporphyrinogen III is reported, while in ...
Hajime MIURA, Seiyo SANO
openaire +2 more sources
Effects of zinc against mercury toxicity in female rats 12 and 48 hours after HgCl2 exposure [PDF]
, 2016 This work investigated the toxicity of inorganic mercury and zinc preventive effects in female rats sacrificed 12 or 48 h after HgCl2 exposure. Female Wistar rats were subcutaneously injected with ZnCl2 (27 mg/kg) or saline (0.9 %), and 24 h later they ...
Bizzi, Cezar Augusto +6 more
core +1 more source