Results 121 to 130 of about 4,692 (177)

The porphobilinogen synthase family of metalloenzymes

Acta Crystallographica Section D: Biological Crystallography, 2000
The porphobilinogen synthase (PBGS) family of enzymes catalyzes the first common step in the biosynthesis of the essential tetrapyrroles such as chlorophyll and porphyrin. Although PBGSs are highly conserved at all four levels of protein structure, there is considerable diversity in the use of divalent cations for the catalytically essential and ...
Eileen K Jaffé
exaly   +3 more sources

Interaction of analogues of porphobilinogen with porphobilinogen deaminase

Journal of the Chemical Society, Perkin Transactions 1, 1996
2-Methylporphobilinogen 5 and 8,9-didehydroporphobilinogen 7 are only weak inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). The phosphonate analogue 8 and 9-fluoroporphobilinogen 9 are good inhibitors, however, and also act as slow substrates (the first unnatural substrates known for this enzyme).
Finian J. Leeper, Martin Rock
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Chemical Synthesis of Porphobilinogen: Synthesis of Porphobilinogen and iso-Porphobilinogen Carboxylic Acids

Nature, 1955
Chemical Synthesis of Porphobilinogen: Synthesis of Porphobilinogen and iso-Porphobilinogen Carboxylic ...
K. S. N. PRASAD, R. RAPER
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Chemical Synthesis of Porphobilinogen: Decarboxylation of Porphobilinogen- and iso-Porphobilinogen-α-Carboxylic Acids

Nature, 1955
Chemical Synthesis of Porphobilinogen: Decarboxylation of Porphobilinogen- and iso-Porphobilinogen-α-Carboxylic ...
C. RIMINGTON, S. KROL
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SYNTHESIS OF PORPHOBILINOGEN

Canadian Journal of Chemistry, 1957
The pyrrole Ib has been converted by several routes into 5-carboxy-porphobilinogen (IIe), the lactam of which is easily decarboxylated to porphobilinogen lactam (IVc). Hydrolysis of the latter gives porphobilinogen (V).
A. H. Jackson, S. F. MacDonald
openaire   +1 more source

Reliability of the porphobilinogen screening assay

Pathology, 1990
A survey conducted by the Australian Association of Clinical Biochemists Porphyrin Working Party on urinary porphobilinogen screening showed good sensitivity (75-97.5%). This is contrary to reports in the literature and to our own observations. We therefore assessed a widely used screening method (Watson-Schwartz) and found poor sensitivity (40-69 ...
J E, Buttery, A M, Carrera, P R, Pannall
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Purification and characterization of animal porphobilinogen synthases—II. Dog liver porphobilinogen synthase

International Journal of Biochemistry, 1982
1. A method is described for the purification of porphobilinogen synthase (PBG-S) from dog liver (acetone dry powder; ammonium sulfate fractionation; controlled heat denaturation; ion exchange chromatography; gel filtration). The 911-fold purified enzyme with a specific activity of 372 mU/mg and 6.2 nkat/mg enzyme protein, respectively, appears as a ...
Zeitler, H.J., Reutzer, M.K., Andondonskaja-Renz, B.   +2 more
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The enzymatic inactivation of porphobilinogen deaminase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1973
Abstract 1. 1. Porphobilinogen deaminase was inhibited by pyrrolooxygenase, a mixed-function oxidase which inhibits tryptophan-containing enzymes in the presence of sodium dithionite. 2. 2. Both enzymes were isolated from wheat germ but it was found that pyrrolooxygenase acted on deaminases from different origins. 3. 3.
R B, Frydman, B, Frydman
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