Results 171 to 180 of about 8,719 (208)
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Nature, 1955
Chemical Synthesis of Porphobilinogen: Decarboxylation of Porphobilinogen- and iso-Porphobilinogen-α-Carboxylic ...
C. RIMINGTON, S. KROL
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Chemical Synthesis of Porphobilinogen: Decarboxylation of Porphobilinogen- and iso-Porphobilinogen-α-Carboxylic ...
C. RIMINGTON, S. KROL
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Interaction of analogues of porphobilinogen with porphobilinogen deaminase
Journal of the Chemical Society, Perkin Transactions 1, 19962-Methylporphobilinogen 5 and 8,9-didehydroporphobilinogen 7 are only weak inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). The phosphonate analogue 8 and 9-fluoroporphobilinogen 9 are good inhibitors, however, and also act as slow substrates (the first unnatural substrates known for this enzyme).
Finian J. Leeper, Martin Rock
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International Journal of Biochemistry, 1982
1. A method is described for the purification of porphobilinogen synthase (PBG-S) from dog liver (acetone dry powder; ammonium sulfate fractionation; controlled heat denaturation; ion exchange chromatography; gel filtration). The 911-fold purified enzyme with a specific activity of 372 mU/mg and 6.2 nkat/mg enzyme protein, respectively, appears as a ...
Zeitler, H.J. +2 more
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1. A method is described for the purification of porphobilinogen synthase (PBG-S) from dog liver (acetone dry powder; ammonium sulfate fractionation; controlled heat denaturation; ion exchange chromatography; gel filtration). The 911-fold purified enzyme with a specific activity of 372 mU/mg and 6.2 nkat/mg enzyme protein, respectively, appears as a ...
Zeitler, H.J. +2 more
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Canadian Journal of Chemistry, 1957
The pyrrole Ib has been converted by several routes into 5-carboxy-porphobilinogen (IIe), the lactam of which is easily decarboxylated to porphobilinogen lactam (IVc). Hydrolysis of the latter gives porphobilinogen (V).
A. H. Jackson, S. F. MacDonald
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The pyrrole Ib has been converted by several routes into 5-carboxy-porphobilinogen (IIe), the lactam of which is easily decarboxylated to porphobilinogen lactam (IVc). Hydrolysis of the latter gives porphobilinogen (V).
A. H. Jackson, S. F. MacDonald
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Archives of General Psychiatry, 1961
A screening procedure for porphobilinogenuria was instituted because there are 4 reasons to expect a higher rate of hepatic porphyria among psychiatric patients than is generally found in other patients. First, acute intermittent porphyria is so closely associated with psychiatric disorder that Roth 1 claimed "porphyria occurs with special frequency ...
R, KAELBLING, J B, CRAIG, B, PASAMANICK
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A screening procedure for porphobilinogenuria was instituted because there are 4 reasons to expect a higher rate of hepatic porphyria among psychiatric patients than is generally found in other patients. First, acute intermittent porphyria is so closely associated with psychiatric disorder that Roth 1 claimed "porphyria occurs with special frequency ...
R, KAELBLING, J B, CRAIG, B, PASAMANICK
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Porphobilinogen oxygenase from human erythrocytes
Clinica Chimica Acta, 1979Porphobilinogen oxygenase was isolated from red cells of healthy persons and of patients with disturbances in porphyrin metabolism. The hemolysates were purified by DEAE-cellulose chromatography and the oxygenase was eluted with either 3 mmol/l phosphate buffer (pH 7.4) or with 10 mmol/l Tris-HCl buffer (pH 7.6).
R B, Frydman, M L, Tomaro, B, Frydman
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Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1977
Porphobilinogen synthase was purified from ox liver by ammonium sulfate fractionation, heat denaturation and column chromatography (purification: 400-fold; specific activity 4.72 nkat). The molecular weight of the native enzyme obtained by thin-layer gel filtration is about 280 000. Using 8M urea in the presence of dithiothreitol as reducing agent, the
M, Kreutzer +3 more
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Porphobilinogen synthase was purified from ox liver by ammonium sulfate fractionation, heat denaturation and column chromatography (purification: 400-fold; specific activity 4.72 nkat). The molecular weight of the native enzyme obtained by thin-layer gel filtration is about 280 000. Using 8M urea in the presence of dithiothreitol as reducing agent, the
M, Kreutzer +3 more
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Nature, 1953
WE recently described a number of reactions of porphobilinogen, from which we concluded that it has the structure (I); but it was not then possible to eliminate the alternative structure in which the positions of the two β-substituents are reversed1.
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WE recently described a number of reactions of porphobilinogen, from which we concluded that it has the structure (I); but it was not then possible to eliminate the alternative structure in which the positions of the two β-substituents are reversed1.
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PYRROLES RELATED TO PORPHOBILINOGEN
Canadian Journal of Chemistry, 1961A study of the decarboxylation of pyrroles related to 5-carboxyporphobilinogen has led to an improved synthesis of porphobilinogen, to isoporphobilinogen, and to other pyrroles required for the preparation of possible intermediates in the biosynthesis of porphyrins.
G. P. Arsenault, S. F. MacDonald
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ChemInform Abstract: PORPHOBILINOGEN‐SYNTH.
Chemischer Informationsdienst, 1973Abstractβ‐Oxo‐adipinsäure‐diäthylester (I) wird mit Pentylnitrit und anschließend mit Acetylaceton in Essigsäure in Gegenwart von Zink und Ammoniumacetat in 50%iger Ausbeute zu dem Acetylpyrrol (II) umgesetzt, das mit Thallium(III)‐ nitrat in‐Methanol das Methoxycarbonylmethyl‐pyrrol (III) ergibt.
G. W. KENNER +2 more
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