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[19] Preparation of porphobilinogen
1970Publisher Summary This chapter illustrates the preparation of porphobilinogen (PBG). PBG is a normal intermediate in the biosynthesis of heme. An enzymatic method has been considered for the preparation of porphobilinogen with good yield using both δ-aminolevulinic acid and the enzyme aminolevulinic acid dehydratase.
H.A. Sancovich +3 more
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Porphobilinogen: Chemical Constitution
Nature, 1953G H, COOKSON, C, RIMINGTON
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The porphobilinogen synthase catalyzed reaction mechanism
Bioorganic Chemistry, 2004Porphobilinogen synthase (PBGS) catalyzes the first common reaction in the biosynthesis of the tetrapyrroles, the asymmetric condensation of two molecules of delta-aminolevulinic acid to form porphobilinogen. There is a variable requirement for an essential active site zinc that necessitates consideration of PBGS as an enzyme that may exhibit ...
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Journal of the Chemical Society, Chemical Communications, 1973
G. W. Kenner +2 more
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G. W. Kenner +2 more
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Determination of erythrocyte porphobilinogen deaminase activity using porphobilinogen as substrate
Clinica Chimica Acta, 1987K J, Hsiao +3 more
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