Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4 [PDF]
, 2013 Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer ...
Fujita, Hirofumi +7 more
core +1 more source
Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management
Liver International, Volume 45, Issue 1, January 2025.Abstract The erythropoietic protoporphyrias consist of three ultra‐rare genetic disorders of the erythroid heme biosynthesis, including erythropoietic protoporphyria (EPP1), X‐linked protoporphyria (XLEPP) and CLPX‐protoporphyria (EPP2), which all lead to the accumulation of protoporphyrin IX (PPIX) in erythrocytes.
Anna‐Elisabeth Minder +4 more
wiley +1 more source
Carrier detection and phenotypic expression in a family with hereditary coproporphyria [PDF]
, 2007 University of Technology, Sydney. Faculty of Science.Introduction: Hereditary coproporphyria (HCP) is an autosomal dominant disorder that results from defects in the enzyme coproporphyrinogen oxidase (CPOX).
Al Hafid, N
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BioTechniques, 2004 We developed a one-step real-time duplex reverse transcription PCR (RT-PCR) method using the LightCycler® platform. This method allows simultaneous reverse transcription and real-time PCR amplification of two mRNAs of specific genes of interest (analyte ...
Chengming Wang +3 more
doaj +1 more source
Sporadic porphyria cutanea tarda due to haemochromatosis [PDF]
, 2006 Haemochromatosis is a hereditary iron-overload syndrome caused by increased intestinal iron absorption and characterised by accumulation of potentially toxic iron in the tissues.
Dees, A., Geus, H.R.H. (Hilde) de
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Long-Term Follow-up of Erythrocyte Porphobilinogen Deaminase Activity in a Patient With Acute Intermittent Porphyria: The Relationship between the Enzyme Activity and Abdominal Pain Attacks [PDF]
, 2007 The relationship between the onset of abdominal pain attack and the urinary levels of δ-aminolevulinic acid, porphobilinogen, uroporphyrin, and the activity of erythrocyte porphobilinogen deaminase was studied on a monthly basis over a four-year period
1242 +7 more
core +1 more source
Bioanalytical studies of porphyric disorders using HPLC with fluorescence detection [PDF]
, 2014 We describe here the development, validation, quantification and application of a method for determination of heme porphyrin precursors in the urine of porphyric patients.
Alves, Atecla Nunciata Lopes +3 more
core +2 more sources
Photochemistry and Photobiology, Volume 100, Issue 6, Page 1541-1560, November/December 2024.Photodynamic therapy (PDT) is now popular for treating nonmelanoma skin cancer (NMSC), but can be ineffective for larger skin tumors, mainly due to inadequate production of PpIX. Work over the past two decades has shown that differentiation‐promoting agents, including methotrexate, 5‐fluorouracil and vitamin D can be combined with ALA‐PDT as ...
Sanjay Anand +2 more
wiley +1 more source
Systematic identification of gene families for use as markers for phylogenetic and phylogeny- driven ecological studies of bacteria and archaea and their major subgroups [PDF]
, 2013 With the astonishing rate that the genomic and metagenomic sequence data sets are accumulating, there are many reasons to constrain the data analyses.
Eisen, Jonathan A. +2 more
core +4 more sources
Variegate Porphyria with Coexistent Decrease in Porphobilinogen Deaminase Activity
Acta Dermato-Venereologica, 2001 Variegate porphyria is a rare disease caused by a deficiency of protoporphyrinogen oxidase. In most cases, the clinical findings are a combination of systemic symptoms similar to those occurring in acute intermittent porphyria and cutaneous lesions indistinguishable from those of porphyria cutanea tarda.
G, Weinlich +3 more
openaire +2 more sources