Results 161 to 170 of about 4,609 (210)
Some of the next articles are maybe not open access.
The enzymatic inactivation of porphobilinogen deaminase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1973Abstract 1. 1. Porphobilinogen deaminase was inhibited by pyrrolooxygenase, a mixed-function oxidase which inhibits tryptophan-containing enzymes in the presence of sodium dithionite. 2. 2. Both enzymes were isolated from wheat germ but it was found that pyrrolooxygenase acted on deaminases from different origins. 3. 3.
R B, Frydman, B, Frydman
openaire +2 more sources
Interaction of analogues of porphobilinogen with porphobilinogen deaminase
Journal of the Chemical Society, Perkin Transactions 1, 19962-Methylporphobilinogen 5 and 8,9-didehydroporphobilinogen 7 are only weak inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). The phosphonate analogue 8 and 9-fluoroporphobilinogen 9 are good inhibitors, however, and also act as slow substrates (the first unnatural substrates known for this enzyme).
Finian J. Leeper, Martin Rock
openaire +1 more source
Characterization of porphobilinogen deaminase from rat liver
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1988Porphobilinogen deaminase (porphobilinogen ammonia-lyase, EC 4.3.1.8) was isolated from rat liver. The final preparation was homogeneous according to polyacrylamide gel electrophoresis and immunodiffusion criteria. Electrophoresis of the native enzyme revealed a single band of activity which was distributed into three bands after incubation with ...
M B, Mazzetti, J M, Tomio
openaire +2 more sources
Porphobilinogen deaminase gene structure and molecular defects
Journal of Bioenergetics and Biomembranes, 1995Porphobilinogen deaminase (PBGD) is the third enzyme of the heme biosynthetic pathway. The half-normal activity of human PBGD causes acute intermittent porphyria (AIP), an autosomal dominant inherited disease. Two PBGD isoforms, one ubiquitous and one erythroid specific, are encoded by a single gene localized to chromosomal region 11q24.1-11q24.2.
J C, Deybach, H, Puy
openaire +2 more sources
Systematic specificity studies on porphobilinogen deaminase
Bioorganic & Medicinal Chemistry Letters, 1994Abstract Analogs of porphobilinogen (PBG) with different arrangements of the acidic side chains at C-3 and C-4 were tested for their ability to form complexes (ESx, x = 1–4) with PBG deaminase (EC 4.3.1.8), the enzyme responsible for the tetramerization of PBG into hydroxymethylbilane (HMB).
Karen R. Clemens +5 more
openaire +1 more source
Protoporphyrinogen oxidase and porphobilinogen deaminase in variegate porphyria
European Journal of Clinical Investigation, 1986Abstract. Two enzymes of the haem biosynthetic pathway were investigated in patients with variegate porphyria. Protoporphyrinogen oxidase in cultures of Epstein‐Barr virus transformed lymphoblasts from twenty‐seven patients showed a mean maximal velocity (Vmax) of 0·39 ± 0·08+ nmol of protoporphyrin mg protein‐1 h‐1, a 52% reduction (P < 0·001 ...
P N, Meissner +4 more
openaire +2 more sources
ELISA for measuring porphobilinogen deaminase in human erythrocytes
Clinica Chimica Acta, 1989An ELISA method has been developed to quantitate human porphobilinogen deaminase in erythrocyte lysate. The antiserum used in the assay was raised against the erythropoietic form of human porphobilinogen deaminase. The IgG fraction was characterized by use of immunoblotting technique, rocket immunoelectrophoresis and immunotitration and shown to be ...
L, Lannfelt +4 more
openaire +2 more sources
Erythrocyte porphobilinogen deaminase activity and primary liver cancer
Journal of Internal Medicine, 1995Abstract. Objectives. To study whether primary liver cancer (PLC) could be associated with acute intermittent porphyria (AIP) carriership and whether the activity of erythrocyte porphobilinogen deaminase (PBGD) could be used as a tumour marker for PLC.Design. Prospective study.Setting.
J, Kaczynski +4 more
openaire +2 more sources