Results 71 to 80 of about 4,609 (210)

Acute hepatic porphyria: when to perform liver transplantation?

Medicina, 2021
Acute hepatic porphyrias (AHPs) are inborn errors of hemebiosynthesis and its most common and severe type is the acute intermittent porphyria (AIP). AIP is an hereditary autosomal dominant disease caused by accumulated porphobilinogen deaminase (PBG) and
Maria Eugênia Carinhani de Cico, Amanda Macedo Sanches Mateus, Bruna Forte Giacheto, Zumira Carneiro, CHARLES MARQUES LOURENCO   +4 more
doaj  

Validation of Reference Genes for Quantitative Real-Time PCR Normalization in Ananas comosus var. bracteatus During Chimeric Leaf Development and Response to Hormone Stimuli

Frontiers in Genetics, 2021
Reverse transcription quantitative real-time PCR (RT-qPCR) is a common way to study gene regulation at the transcriptional level due to its sensibility and specificity, but it needs appropriate reference genes to normalize data.
Meiqin Mao, Yanbin Xue, Yehua He, Xuzixing Zhou, Hao Hu, Jiawen Liu, Lijun Feng, Wei Yang, Jiaheng Luo, Huiling Zhang, Xi Li, Jun Ma   +11 more
doaj   +1 more source

General anaesthesia in acute intermittent porphyria [PDF]

, 2014
Acute intermittent porphyria (AIP) is caused by the deficiency of porphobilinogen deaminase, a haem synthesis enzyme, giving rise to crises characterized by abdominal pain, tachyarrythmias and psychiatric features.
Abela, Glenn Paul, Calleja, Paul
core  

Sulfate Reduction in Sediments Produces High Levels of Chromophoric Dissolved Organic Matter [PDF]

, 2017
Sulfate reduction plays an important role in altering dissolved organic matter (DOM) in estuarine and coastal sediments, although its role in the production of optically active chromophoric DOM (CDOM) and a subset of fluorescent DOM (FDOM) has not been ...
Gonsior, Michael, Heyes, Andrew, Larsen, Randolph K., Luek, Jenna L., Thompson, Kaitlyn E.   +4 more
core   +2 more sources

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

MedComm, Volume 6, Issue 10, October 2025.
This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li, Junli Li, Jiazheng Wei, Weixin Du, Cheng Su, Xiaobin Shen, Aihua Zhao, Miao Xu   +7 more
wiley   +1 more source

δ-Aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines [PDF]

, 2002
BACKGROUND: Acute Intermittent Porphyria is a genetic disorder of heme metabolism, characterized by increased levels of porphyrin precursors, delta-aminolevulinic acid (ALA) and porphobilinogen (PBG).
Adriana De Siervi, Elba S Vazquez, Carolina Rezaval, María V Rossetti, Alcira M del Batlle, LA Wetterberg, C AM del Batlle, A De Siervi, JA Stein, HL Bonkowsky, EA Wider de Xifra, F Lithner, L Hardell, R Kauppinen, J Onuki, DP Aden, BB Knowles, GJ Darlington, B Bressac, JK Wilson, P Chomczynski, T Douki, A Batlle, S Helson, R Washbrook, F Wagener, K Nath, V Russel, MC Raff, SW Lowe, L Meijer, M Garrett   +31 more
core   +4 more sources

Delivering the Message: Translating mRNA Therapy for Liver Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT mRNA encapsulated in lipid nanoparticles (LNPs) provides a dual revolution in the field of gene therapy. mRNA brings fleeting efficacy and the possibility to adjust the therapy to clinical needs. LNP, as a non‐viral vehicle with flexible organ‐targeting, overcomes most immune complications of viral gene therapy. mRNA‐LNP has rapidly progressed
Sonam Gurung, Dany Perocheau, Roopkatha Ghosh, Stephen L. Hart, Julien Baruteau   +4 more
wiley   +1 more source

Heat-induced Leaf Senescence in Creeping Bentgrass Suppressed by Aminoethoxyvinylglycine Involving Regulation of Chlorophyll Metabolism

Journal of the American Society for Horticultural Science, 2023
Heat stress-induced or stress-accelerated leaf senescence is related to the accumulation of ethylene and loss of chlorophyll in cool-season grass species.
Stephanie Rossi, Bingru Huang
doaj   +1 more source

Nuclear distribution of porphobilinogen deaminase (PBGD) in glioma cells: a regulatory role in cancer transformation? [PDF]

Recently, considerable interest has been directed to red-fluorescence photodiagnosis of brain and other tumours during surgery using the protoporphyrin IX natural precursor, 5-aminolaevulinic acid.
Gozlan, Y, Greenbaum, L, Katcoff, D J, Malik, Z, Schwartz, D   +4 more
core   +2 more sources

Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in response to different nutrients [PDF]

, 2016
Distribution of total clean tags and distinct clean tags over different tag abundance categories. Numbers in square brackets demonstrate the range of copy numbers for a specific category of tags.
Kai Jin, Yuxian Xia, Zhenglong Wang
core   +11 more sources