Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388 [PDF]
Pharmacology Research and Perspectives, 2020 COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Mai Nguyen +2 more
exaly +4 more sources
Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs [PDF]
Frontiers in Veterinary Science, 2023 Previous research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA ...
Michiyo Matsumoto-Nakano +2 more
exaly +4 more sources
Phylogenomic analysis of the Porphyromonas gingivalis - Porphyromonas gulae duo: approaches to the origin of periodontitis [PDF]
Frontiers in Microbiology, 2023 Porphyromonas gingivalis is an oral human pathogen associated with the onset and progression of periodontitis, a chronic immune-inflammatory disease characterized by the destruction of the teeth-supporting tissue. P.
Josefa Nuñez-Belmar +2 more
exaly +4 more sources
Phylogenetic diversity in fim and mfa gene clusters between Porphyromonas gingivalis and Porphyromonas gulae, as a potential cause of host specificity [PDF]
Journal of Oral Microbiology, 2020 Background Periodontopathic bacteria Porphyromonas gingivalis in humans and Porphyromonas gulae in animals are phylogenetically close and commonly have FimA and Mfa1 fimbriae.
Takayasu Watanabe +2 more
exaly +3 more sources
Efficacy of FimA antibody and clindamycin in silkworm larvae stimulated with Porphyromonas gulae [PDF]
Journal of Oral Microbiology, 2021 Objective: Porphyromonas gulae, a major periodontal pathogen in animals, possesses fimbriae that have been classified into three genotypes (A, B, C) based on the diversity of fimA genes encoding fimbrillin protein (FimA). P.
Hiroaki Inaba +2 more
exaly +3 more sources
Purification and characterization of a novel secondary fimbrial protein fromPorphyromonas gulae [PDF]
Journal of Oral Microbiology, 2012 Background: Porphyromonas gulae are black-pigmented anaerobic bacteria isolated from the gingival sulcus of various animal hosts and are distinct from Porphyromonas gingivalis originating in humans. We previously reported the antigenic similarities of 41-
Kiyoko Watanabe +2 more
exaly +4 more sources
Whole mastic resin ameliorates halitosis and gingivitis in dogs and cats infected with Porphyromonas gulae [PDF]
Scientific ReportsMastic, a natural resin, has long been used to prevent periodontal disease, but most studies focus on mastic extracts rather than the resin itself.
Mao Kaneki +2 more
exaly +3 more sources
Porphyromonas gulae and canine periodontal disease: Current understanding and future directions [PDF]
VirulencePorphyromonas gulae has emerged as a notable pathogen in canine periodontal disease, akin to Porphyromonas gingivalis in human periodontitis. This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host ...
Kyu Hwan Kwack +2 more
exaly +4 more sources
Volatile Sulfur Compounds Produced by the Anaerobic Bacteria Porphyromonas spp. Isolated from the Oral Cavities of Dogs [PDF]
Veterinary Sciences, 2023 Porphyromonas spp. are oral anaerobic Gram-negative bacteria that form black-pigmented colonies on blood agar and produce volatile sulfur compounds (VSCs), such as hydrogen sulfide (H2S), methyl mercaptan (CH3SH), and dimethyl sulfide ((CH3)2S), which ...
Noriyuki Ito +2 more
doaj +2 more sources
Adhesion and invasion of gingival epithelial cells by Porphyromonas gulae. [PDF]
PLoS ONE, 2019 Porphyromonas gulae, an animal periodontal pathogen, possess fimbriae classified into three genotypes (A-C) based on the diversity of fimA genes encoding FimA. Accumulating evidence suggests that P. gulae strains with type C fimbriae are more virulent as
Hiroaki Inaba +8 more
doaj +2 more sources