Results 191 to 200 of about 2,751,808 (304)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong   +8 more
wiley   +1 more source

The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models

open access: yesAdvanced Science, EarlyView.
Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková   +5 more
wiley   +1 more source

Development and characterization of coaxial two-way switch for RF plasma discharge experiments. [PDF]

open access: yesSci Rep
Singh R   +7 more
europepmc   +1 more source

Hierarchical Reconfigurable Metasurface Based on Scenario‐Guided Functional Modules and Programmable Core

open access: yesAdvanced Science, EarlyView.
This paper proposes a hierarchical reconfigurable metasurface architecture (HRMA) to achieve comprehensive electromagnetic parameter modulation and on‐demand polymorphic function switching. The reconfigurable metasurface is divided into a programmable core (PC) and scenario‐guided functional modules (FMs), exhibiting significant flexibility and ...
Lihao Zhu   +11 more
wiley   +1 more source

Graphene‐Skinned Alumina Fiber: Continuously Scalable Fabrication and Its Electrothermal Application in Fiber‐Reinforced Polymer Composites

open access: yesAdvanced Science, EarlyView.
Graphene‐skinned alumina fiber (GAF) is a new composite with graphene conformally grown on individual alumina fibers via chemical vapor deposition (CVD). GAF's dynamic, continuous and scalable production is achieved by using a home‐made roll‐to‐roll (RTR) CVD system featuring integrated degumming and growth chambers. GAF possesses tunable conductivity,
Xiaobai Wang   +13 more
wiley   +1 more source

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