Results 31 to 40 of about 114,857 (246)

Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin‐mediated deacetylation

Aging Cell, Volume 22, Issue 7, July 2023., 2023
Ammonia is an endogenous cytotoxin that causes post‐mitotic senescence but the molecular mechanisms are poorly understood. Complementary multiomics, molecular, and metabolic analyses across a comprehensive array of preclinical models and human skeletal muscle show that mitochondrial oxidative dysfunction results in impaired oxidation of NADH with redox
Saurabh Mishra, Nicole Welch, Manikandan Karthikeyan, Annette Bellar, Ryan Musich, Shashi Shekhar Singh, Dongmei Zhang, Jinendiran Sekar, Amy H. Attaway, Aruna Kumar Chelluboyina, Shuhui Wang Lorkowski, Sanjoy Roychowdhury, Ling Li, Belinda Willard, Jonathan D. Smith, Charles L. Hoppel, Vidula Vachharajani, Avinash Kumar, Srinivasan Dasarathy   +18 more
wiley   +1 more source

Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis [PDF]

Hepatology, 1999
Sonali Master, Jeanne Gottstein, Andrés T. Blei   +2 more
openalex   +2 more sources

Preoperative portal vein recanalization–transjugular intrahepatic portosystemic shunt for chronic obliterative portal vein thrombosis: Outcomes following liver transplantation

Hepatology Communications, Volume 6, Issue 7, Page 1803-1812, July 2022., 2022
Patients with chronic, obliterative portal vein thrombosis may be converted to liver transplantation candidacy following portal vein recanalization‐transjugular intrahepatic portosystemic shunt (PVR‐TIPS). Long‐term survival outcomes of patients with chronic, obliterative portal vein thrombosis who undergo transplantation following PVR‐TIPS are similar
Abhinav Talwar, Jeffrey Varghese, Gabriel M. Knight, Nitin Katariya, Juan‐Carlos Caicedo, Zach Dietch, Daniel Borja‐Cacho, Daniella Ladner, Derrick Christopher, Talia Baker, Michael Abecassis, Samdeep Mouli, Kush Desai, Ahsun Riaz, Bart Thornburg, Riad Salem   +15 more
wiley   +1 more source

Portacaval shunt established in six dogs using magnetic compression technique. [PDF]

PLoS ONE, 2013
BACKGROUND AND AIMS: Installing the transjugular intrahepatic portosystemic shunt for portal hypertension is relatively safe, but complications are still high. To explore a new method of portacaval shunt, the magnetic compression technique was introduced
Xiaopeng Yan, Chao Fan, Jia Ma, Jianhui Li, Dinghui Dong, Haohua Wang, Feng Ma, Xinglong Zheng, Yi Lv   +8 more
doaj   +1 more source

Effects of the histamine H1 receptor blocker, pyrilamine, on spontaneous locomotor activity of rats with long-term portacaval anastomosis [PDF]

Hepatology, 2000
V. Lozeva, Antti Valjakka, Anne Lecklin, H. Olkkonen, Mikko Hippeläinen, Matti Itkonen, Carme Plumed, Leena Tuomisto   +7 more
openalex   +2 more sources

Liver Transplant Imaging prior to and during the COVID‐19 Pandemic

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Background. The suspension of the surgical activity, the burden of the infection in immunosuppressed patients, and the comorbidities underlying end‐stage organ disease have impacted transplant programs significantly, even life‐saving procedures, such as liver transplantation. Methods.
Maria Irene Bellini, Daniele Fresilli, Augusto Lauro, Gianluca Mennini, Massimo Rossi, Carlo Catalano, Vito D’Andrea, Vito Cantisani, Gernot Kaiser   +8 more
wiley   +1 more source

Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes

Liver Transplantation, Volume 26, Issue 12, Page 1629-1643, December 2020., 2020
Orthotopic liver transplantation continues to be the only effective therapy for patients with end‐stage liver disease. Unfortunately, many of these patients are not considered transplant candidates, lacking effective therapeutic options that would address both the irreversible progression of their hepatic failure and the control of their portal ...
Paulo Fontes, Junji Komori, Roberto Lopez, Wallis Marsh, Eric Lagasse   +4 more
wiley   +1 more source

Histamine‐induced plasticity and gene expression in corticostriatal pathway under hyperammonemia

CNS Neuroscience &Therapeutics, Volume 26, Issue 3, Page 355-366, March 2020., 2020
Abstract Aims Histamine H3 receptor (H3R) antagonists/inverse agonists increase vigilance. We studied brain histaminergic pathways under hyperammonemia and the transcriptome of receptors and their signaling cascades to provide a rationale for wake‐promoting therapies.
Olga A. Sergeeva, Aisa N. Chepkova, Boris Görg, Filipe Rodrigues Almeida, Hans‐Jürgen Bidmon, Helmut L. Haas, Dieter Häussinger   +6 more
wiley   +1 more source

Critical Analysis of Stage IV Epithelial Ovarian Cancer Patients after Treatment with Neoadjuvant Chemotherapy followed by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC)

International Journal of Surgical Oncology, Volume 2020, Issue 1, 2020., 2020
Background. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) after neoadjuvant chemotherapy (NACT) showed promise as initial treatment for stage IIIC (SIII) epithelial ovarian cancer (EOC); however, stage IV (SIV) outcomes are rarely reported.
Carlos A. Munoz-Zuluaga, Armando Sardi, Michelle Sittig, Vadim Gushchin, Mary C. King, Carol Nieroda, Felipe Lopez-Ramirez, Teresa P. Diaz-Montes, C. H. Yip   +8 more
wiley   +1 more source

Small bowel transplantation in outbred rats Transplante de intestino delgado em ratos não-isogênicos

Acta Cirúrgica Brasileira, 2011
PURPOSE: To investigate the clinical evolution of orthotopic small bowel transplantation in outbred rats. METHODS: Seventy-two outbred Wistar rats weighting from 250 to 300g were used as donor and recipient in 36 consecutives ortothopic small intestine ...
Daniel Reis Waisberg, André Dong Wong Lee, Rafael Miyashiro Nunes dos Santos, Eduardo Kenji Mory, Anderson Lino Costa, Edna Frasson de Souza Montero, Eleazar Chaib, Luis Augusto Carneiro D'Albuquerque, Flavio Henrique Ferreira Galvao   +8 more
doaj   +1 more source