Results 21 to 30 of about 2,270 (143)
Clinical Pharmacology in Drug Development, Volume 10, Issue 7, Page 707-717, July 2021., 2021 Abstract This phase I open‐label trial (NCT03627754) assessed glasdegib pharmacokinetics and safety in otherwise healthy participants with moderate (Child‐Pugh B) or severe (Child‐Pugh C) hepatic impairment. Participants with hepatic impairment and age/weight‐matched controls with normal hepatic function received a single oral 100‐mg glasdegib dose ...
Joanna C. Masters +4 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 37, Issue 5, Page 355-360, May 2021., 2021 Abstract Vascular liver disease (VLD) presents special challenges in the diagnosis, surveillance, and treatment of hepatocellular carcinoma (HCC). HCC arising in the setting of vascular liver disease is often thought to be due to elevated hepatic arterial blood flow, rather than progressive fibrosis from chronic inflammation as with other chronic liver
Debi Prasad, Mindie H. Nguyen
wiley +1 more source
ESC Heart Failure, Volume 8, Issue 1, Page 129-138, February 2021., 2021 Abstract Aims In patients at high risk of heart failure following myocardial infarction (MI) as a result of residual left ventricular systolic dysfunction (LVSD), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan may result in a greater attenuation of adverse left ventricular (LV) remodelling than renin angiotensin aldosterone system ...
Kieran F. Docherty +11 more
wiley +1 more source
Malignant Priapism as a Result of Metastatic Thyroid Cancer: A Hard Reality
Case Reports in Urology, Volume 2021, Issue 1, 2021., 2021 Metastasis to the penis is an extremely rare entity. Malignant priapism is defined as a persistent, nonsexual erection that is refractory to pharmacologic treatment, corporal aspiration, and surgical shunts. Furthermore, it is typically a hallmark of an advanced cancer that has metastasized, most commonly from regional organs like the prostate or ...
Ethan Vargo +5 more
wiley +1 more source
Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes
Liver Transplantation, Volume 26, Issue 12, Page 1629-1643, December 2020., 2020 Orthotopic liver transplantation continues to be the only effective therapy for patients with end‐stage liver disease. Unfortunately, many of these patients are not considered transplant candidates, lacking effective therapeutic options that would address both the irreversible progression of their hepatic failure and the control of their portal ...
Paulo Fontes +4 more
wiley +1 more source
The Role of Neuroinflammation in the Pathogenesis of Hepatic Encephalopathy
Journal of Immunology Research, Volume 2025, Issue 1, 2025.Liver disease impacts millions of Americans every year, which is compounded by the comorbidities and consequences that patients are susceptible to developing. Hepatic encephalopathy (HE) is a severe consequence of liver failure resulting in a range of cognitive deficits that heavily impact quality of life. Approximately 40% of acute liver failure (ALF)
Kathryn Rhodes +3 more
wiley +1 more source
Canadian Journal of Gastroenterology and Hepatology, Volume 2019, Issue 1, 2019., 2019 Sarcopenia is a common complication of cirrhosis with a negative impact on posttransplant outcome, health‐related quality of life (HRQOL), and patient survival. Studies in experimental animals and in patients demonstrate that ammonia is directly implicated in the pathogenesis of sarcopenia in cirrhosis via mechanisms involving increased expression of ...
Roger F. Butterworth, Quirino Lai
wiley +1 more source
Canadian Journal of Gastroenterology and Hepatology, Volume 2018, Issue 1, 2018., 2018 We aimed to evaluate the safety and efficacy of low doses of anti‐T‐lymphocyte globulin (ATG)‐based immunosuppression in preserving renal function and preventing liver rejection in liver transplant (LT) recipients with pretransplant renal dysfunction. We designed a prospective single‐center cohort study analyzing patients with pre‐LT renal dysfunction ...
Cristina Dopazo +8 more
wiley +1 more source
Cadaveric small bowel and small bowel-liver transplantation in humans [PDF]
, 1992 Five patients had complete cadaveric small bowel transplants under FK506 immunosuppression, one as an isolated graft and the other 4 in continuity with a liver. Three were children and two were adults.
Abu-Elmagd, K +13 more
core +1 more source
Small‐for‐size liver transplanted into larger recipient: A model of hepatic regeneration [PDF]
, 1994 Orthotopic liver transplantation was performed in 60 recipient rats weighing 200 to 250 gm. Sixty rats of the same strain were used as liver donors, 30 weighing 100 to 140 gm (small for size) and the other 30 weighing 200 to 250 gm (same size).
Carr, BI +7 more
core +1 more source