Results 21 to 30 of about 24,991 (171)
Portal Hypertension &Cirrhosis, Volume 1, Issue 2, Page 133-144, September 2022., 2022 Prognostic tools for survival prediction and risk stratification after transjugular intrahepatic portosystemic shunt placement. Abstract Patient prognosis after transjugular intrahepatic portosystemic shunt (TIPS) placement is relatively poor and highly heterogeneous; therefore, a prognostic scoring system is essential for survival prediction and risk ...
Chongtu Yang, Bin Xiong
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The Journal of Clinical Pharmacology, Volume 62, Issue 6, Page 812-822, June 2022., 2022 Abstract Acalabrutinib received approval for the treatment of adult patients with mantle cell lymphoma who received at least 1 prior therapy and adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. This study investigated the impact of hepatic impairment (HI) on acalabrutinib pharmacokinetics (PK) and safety at a single 50‐mg
Yan Xu +13 more
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Late Bleeding Episodes Following Intestinal Transplantation
JPGN Reports, Volume 3, Issue 2, May 2022., 2022 Ectopic varices have been reported in 5% of children presenting with variceal bleeding and are defined as portosystemic venous collaterals occurring anywhere in the abdomen except in the cardioesophageal region. The liver‐intestinal transplant or isolated liver‐intestinal transplant patient presenting several years post‐transplant with ectopic variceal
Harveen Singh +6 more
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Clinical Pharmacology in Drug Development, Volume 10, Issue 7, Page 707-717, July 2021., 2021 Abstract This phase I open‐label trial (NCT03627754) assessed glasdegib pharmacokinetics and safety in otherwise healthy participants with moderate (Child‐Pugh B) or severe (Child‐Pugh C) hepatic impairment. Participants with hepatic impairment and age/weight‐matched controls with normal hepatic function received a single oral 100‐mg glasdegib dose ...
Joanna C. Masters +4 more
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ESC Heart Failure, Volume 8, Issue 1, Page 129-138, February 2021., 2021 Abstract Aims In patients at high risk of heart failure following myocardial infarction (MI) as a result of residual left ventricular systolic dysfunction (LVSD), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan may result in a greater attenuation of adverse left ventricular (LV) remodelling than renin angiotensin aldosterone system ...
Kieran F. Docherty +11 more
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Malignant Priapism as a Result of Metastatic Thyroid Cancer: A Hard Reality
Case Reports in Urology, Volume 2021, Issue 1, 2021., 2021 Metastasis to the penis is an extremely rare entity. Malignant priapism is defined as a persistent, nonsexual erection that is refractory to pharmacologic treatment, corporal aspiration, and surgical shunts. Furthermore, it is typically a hallmark of an advanced cancer that has metastasized, most commonly from regional organs like the prostate or ...
Ethan Vargo +5 more
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Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes
Liver Transplantation, Volume 26, Issue 12, Page 1629-1643, December 2020., 2020 Orthotopic liver transplantation continues to be the only effective therapy for patients with end‐stage liver disease. Unfortunately, many of these patients are not considered transplant candidates, lacking effective therapeutic options that would address both the irreversible progression of their hepatic failure and the control of their portal ...
Paulo Fontes +4 more
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HPB, 2015 Hepatic tumours located at the hepatocaval confluence or compromising the inferior vena cava (IVC) are not often resectable using conventional techniques. To overcome this problem, different surgical procedures have been described.
E. de Santibañes +6 more
semanticscholar +1 more source
Canadian Journal of Gastroenterology and Hepatology, Volume 2019, Issue 1, 2019., 2019 Sarcopenia is a common complication of cirrhosis with a negative impact on posttransplant outcome, health‐related quality of life (HRQOL), and patient survival. Studies in experimental animals and in patients demonstrate that ammonia is directly implicated in the pathogenesis of sarcopenia in cirrhosis via mechanisms involving increased expression of ...
Roger F. Butterworth, Quirino Lai
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Journal of Gastrointestinal Surgery, 2010 BackgroundEmergency treatment of bleeding esophageal varices (BEV) in cirrhotic patients is of prime importance because of the high mortality rate surrounding the episode of acute bleeding. Nevertheless, there is a paucity of randomized controlled trials
M. Orloff +7 more
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