Results 11 to 20 of about 4,886 (183)

Late Bleeding Episodes Following Intestinal Transplantation: It Is Not Always Rejection or Infection. [PDF]

open access: yesJPGN Rep, 2022
Ectopic varices have been reported in 5% of children presenting with variceal bleeding and are defined as portosystemic venous collaterals occurring anywhere in the abdomen except in the cardioesophageal region. The liver‐intestinal transplant or isolated liver‐intestinal transplant patient presenting several years post‐transplant with ectopic variceal
Singh H   +6 more
europepmc   +2 more sources

A Challenging Case of Refractory Hepatic Encephalopathy in a Postliver Retransplant Patient with Thrombosed Portal Vein: A Shunt for a Shunt. [PDF]

open access: yesCase Reports Hepatol, 2023
Hepatic encephalopathy (HE) is a frequent and serious complication of chronic liver disease. The mechanism of hepatic encephalopathy is not entirely clear. Hepatic encephalopathy is defined as brain dysfunction caused by liver insufficiency and/or portal‐systemic blood shunting.
Salama F   +3 more
europepmc   +2 more sources

Glycogen storage disease type I: Genetic etiology, clinical manifestations, and conventional and gene therapies

open access: yesPediatric Discovery, Volume 1, Issue 2, September 2023., 2023
Abstract Glycogen storage disease type I (GSDI) is an inherited metabolic disorder characterized by a deficiency of enzymes or proteins involved in glycogenolysis and gluconeogenesis, resulting in excessive intracellular glycogen accumulation. While GSDI is classified into four different subtypes based on molecular genetic variants, GSDIa accounts for ...
Jiamin Zhong   +10 more
wiley   +1 more source

The GABA system, a new target for medications against cognitive impairment—Associated with neuroactive steroids

open access: yesJournal of Internal Medicine, Volume 294, Issue 3, Page 281-294, September 2023., 2023
Abstract The prevalence of cognitive dysfunction, dementia, and neurodegenerative disorders such as Alzheimer's disease (AD) is increasing in parallel with an aging population. Distinct types of chronic stress are thought to be instrumental in the development of cognitive impairment in central nervous system (CNS) disorders where cognitive impairment ...
Torbjörn Bäckström   +4 more
wiley   +1 more source

Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 2, Page 261-273, February 2023., 2023
Abstract Physiologically based pharmacokinetic models, populated with drug‐metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the pharmacokinetics (PK) of drugs. To increase confidence in the predictive power of such models, they must be validated by comparing the predicted and observed
Mayur K. Ladumor   +7 more
wiley   +1 more source

Coagulation Dysfunction in Patients with Liver Cirrhosis and Splenomegaly and Its Countermeasures: A Retrospective Study of 1522 Patients

open access: yesDisease Markers, Volume 2023, Issue 1, 2023., 2023
Objective. Patients with cirrhosis and splenomegaly often have coagulation dysfunction which affects treatment and prognosis. This study explores the status, grading, and treatment strategies of coagulation dysfunction in patients with liver cirrhosis and splenomegaly. Methods.
Yunfu Lv   +7 more
wiley   +1 more source

A modified microsurgical model for end-to-side selective portacaval shunt in the rat: intraoperative microcirculatory investigations [PDF]

open access: yesActa Cirúrgica Brasileira, 2013
PURPOSE: To investigate the intraoperative microcirculatory changes of the affected organs (small bowel, liver and kidney) during the making of a modified selective portacaval (PC) shunt.
Zoltan Klarik   +5 more
doaj   +2 more sources

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