Results 31 to 40 of about 4,879 (225)

Pediatric liver transplantation using a hepatitis B surface antigen-positive donor liver graft for congenital absence of the portal vein

Korean Journal of Transplantation, 2021
Congenital absence of the portal vein (CAPV) is a rare venous malformation in which mesenteric venous blood drains directly into systemic circulation. Herein, we report a case of pediatric deceased donor liver transplantation (DDLT) for symptomatic CAPV ...
Jung-Man Namgoong, Shin Hwang, Dae-Yeon Kim, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Kyung Mo Kim, Seak Hee Oh   +7 more
doaj   +1 more source

Differential production of interleukin‐6 and tumor necrosis factor‐α in primary rat astrocyte cultures using two distinct methods of microglia elimination

Clinical and Experimental Neuroimmunology, Volume 12, Issue 3, Page 192-201, August 2021., 2021
This study examines the effect of the most important factors involved in hepatic encephalopathy on the production of reactive oxygen species and cytokines such as tumor necrosis factor‐α and interleukin‐6 in highly purified primary rat astrocyte cultures. Results demonstrated that manganese evoked oxidative stress in a time‐dependent manner.
Zoltan Barany, Istvan Toth, Gergely Jocsak, Laszlo V. Frenyo, Tibor Bartha, Agnes Sterczer, David S. Kiss   +6 more
wiley   +1 more source

Pharmacokinetics and Safety of Glasdegib in Participants With Moderate/Severe Hepatic Impairment: A Phase I, Single‐Dose, Matched Case‐Control Study

Clinical Pharmacology in Drug Development, Volume 10, Issue 7, Page 707-717, July 2021., 2021
Abstract This phase I open‐label trial (NCT03627754) assessed glasdegib pharmacokinetics and safety in otherwise healthy participants with moderate (Child‐Pugh B) or severe (Child‐Pugh C) hepatic impairment. Participants with hepatic impairment and age/weight‐matched controls with normal hepatic function received a single oral 100‐mg glasdegib dose ...
Joanna C. Masters, Robert R. LaBadie, Joanne Salageanu, Jerry Li, Naveed Shaik   +4 more
wiley   +1 more source

Epidemiology, pathogenesis, diagnosis, surveillance, and management of hepatocellular carcinoma associated with vascular liver disease

The Kaohsiung Journal of Medical Sciences, Volume 37, Issue 5, Page 355-360, May 2021., 2021
Abstract Vascular liver disease (VLD) presents special challenges in the diagnosis, surveillance, and treatment of hepatocellular carcinoma (HCC). HCC arising in the setting of vascular liver disease is often thought to be due to elevated hepatic arterial blood flow, rather than progressive fibrosis from chronic inflammation as with other chronic liver
Debi Prasad, Mindie H. Nguyen
wiley   +1 more source

Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling

ESC Heart Failure, Volume 8, Issue 1, Page 129-138, February 2021., 2021
Abstract Aims In patients at high risk of heart failure following myocardial infarction (MI) as a result of residual left ventricular systolic dysfunction (LVSD), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan may result in a greater attenuation of adverse left ventricular (LV) remodelling than renin angiotensin aldosterone system ...
Kieran F. Docherty, Ross T. Campbell, Katriona J.M. Brooksbank, Rosemary L. Godeseth, Paul Forsyth, Alex McConnachie, Giles Roditi, Bethany Stanley, Paul Welsh, Pardeep S. Jhund, Mark C. Petrie, John J.V. McMurray   +11 more
wiley   +1 more source

Diagnosis and management of a pediatric portacaval shunt: An uncommon cause of cyanosis in children

Research in Cardiovascular Medicine, 2017
Introduction: Congenital portosystemic shunts constitute a rare disorder in childhood with a wide spectrum of symptoms and signs, one of which may be cyanosis.
Hojjat Mortezaeian, Mohammad Rafie Khorgam, Hamidreza Pouraliakbar, Ali Jafarian   +3 more
doaj   +1 more source

Effect of cyclosporine on hepatic energy status and on fructose metabolism after portacaval shunt in dog as monitored by phosphorus‐31 nuclear magnetic resonance spectroscopy in vivo [PDF]

, 1991
The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus‐31 nuclear magnetic resonance spectroscopy in dogs.
Atkinson, Avison, Baldassarri, Bode, Bäckman, Calne, Cohen, Evelhoch, Francavilla, Grant, Harder, Iles, Iles, Kahn, Kim, Kim, Klintmalm, Laupacis, Loertscher, Lorber, Makowka, Mazzaferro, Otte, Powles, Roos, Rossaro, Schade, Seo, Stacey, Starzl, Starzl, Starzl, Starzl, Starzl, Stone, Thompson, Van Thiel, Ziegler   +37 more
core   +1 more source

Malignant Priapism as a Result of Metastatic Thyroid Cancer: A Hard Reality

Case Reports in Urology, Volume 2021, Issue 1, 2021., 2021
Metastasis to the penis is an extremely rare entity. Malignant priapism is defined as a persistent, nonsexual erection that is refractory to pharmacologic treatment, corporal aspiration, and surgical shunts. Furthermore, it is typically a hallmark of an advanced cancer that has metastasized, most commonly from regional organs like the prostate or ...
Ethan Vargo, Bryson Cook, Jason Lane, Eric Speakman, Neel Parekh, Claudio Simeone   +5 more
wiley   +1 more source

Prospective analysis of 44 consecutive liver transplants performed at a university hospital [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To analyze the intraoperative and immediate postoperative biochemical parameters of patients submitted to orthotopic liver transplantation. METHODS: Forty four consecutive orthotopic liver transplants performed from October 2009 to December 2010
Orlando Castro e Silva, Priscila Nejo, Nathalia Cardoso, Enio David Mente, Fernanda Fernandes Souza, Andreza Corrêa Teixeira, Thiago Freitas, Daniel Cagnolati   +7 more
doaj   +3 more sources

Hepatic proliferation and angiogenesis markers are increased after portal deprivation in rats: a study of molecular, histological and radiological changes. [PDF]

PLoS ONE, 2015
To determine the pathogenesis of liver nodules, and lesions similar to obliterative portal venopathy, observed after portosystemic shunts or portal vein thrombosis in humans.We conducted an experimental study comparing portacaval shunt (PCS), total ...
Florent Guérin, Mathilde Wagner, Antoine Liné, Magaly Zappa, Magali Fasseu, Valérie Paradis, Valérie Vilgrain, Bernard E Van Beers, Josette Legagneux, Richard Moreau, Philippe Lettéron   +10 more
doaj   +1 more source