Results 171 to 180 of about 402,815 (326)

Interrelationships of portal pressure, variceal size, and upper gastrointestinal bleeding

, 1980
Telfer B. Reynolds
openalex   +1 more source

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source

Persistent varices in cured patients: Understanding the role of hepatic venous pressure gradient

JHEP Reports
Background & Aims: Etiologic factor removal (ER) drives recompensation and improves portal hypertension in cirrhosis. Esophageal varices (EV) and portosystemic shunts (PSS) have been found in patients despite hepatic venous pressure gradient (HVPG ...
Pol Olivas, Alexandre Soler-Perromat, Luis Tellez, José Antonio Carrión, Edilmar Alvarado-Tapias, José Ferrusquía-Acosta, Sabela Lens, Antonio Guerrero, Ángeles Falgà, Pamela Vizcarra, Lara Orts, Valeria Perez-Campuzano, Sarah Shalaby, Sonia Torres, Anna Baiges, Fanny Turon, Juan Carlos García-Pagán, Ángeles García-Criado, Virginia Hernández-Gea   +18 more
doaj  

Correlation Between Portal Pressure and Indocyanine Green Retention Rate is Unaffected by the Cause of Cirrhosis: A Prospective Study. [PDF]

World J Surg, 2021
Kobayashi K, Uldry E, Kokudo T, Cristaudi A, Kawaguchi Y, Shirata C, Yamaguchi T, Dormond O, Duran R, Hasegawa K, Demartines N, Halkic N.   +11 more
europepmc   +1 more source

First‐in‐Human Study of Merotocin, a Short‐Acting Peptidic Oxytocin Receptor Agonist for Lactation Support

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Endogenous oxytocin plays an important role in lactation, but its effectiveness as an exogenous galactagogue has been modest due to dose‐limiting side effects related to off‐target effects at the vasopressin V2 receptor. Merotocin (FE 202767) is a short‐acting peptidic oxytocin receptor agonist with the potential to aid mothers experiencing ...
Yu Bagger, Carina Holmqvist, Daniël M. Jonker, Bjarke M. Klein, Lorien E. Urban   +4 more
wiley   +1 more source

Significance of Corrected Sinusoidal Pressure (CSP) in Patients with Cirrhosis and Portal Hypertension

, 1981
Michael K. McLeod, Frederic E. Eckhäuser, Jeremiah G. Turcotte   +2 more
openalex   +2 more sources

Progress in Pharmacogenomics Implementation in the United States: Barrier Erosion and Remaining Challenges

Clinical Pharmacology &Therapeutics, EarlyView.
Barriers to incorporating pharmacogenetics into routine clinical practice in the United States are well documented. Initial surveys by the Clinical Pharmacogenetics Implementation Consortium (CPIC) in 2009 and 2010 identified barriers across four key domains that have hindered the widespread adoption of clinical pharmacogenetic testing.
D. Max Smith, Michael P. Douglas, Christina L. Aquilante, Patricia A. Deverka, Beth Devine, Henry M. Dunnenberger, Philip E. Empey, Daniel L. Hertz, Andrew A. Monte, Ann M. Moyer, Jai N. Patel, Victoria M. Pratt, Loren Saulsberry, Stuart A. Scott, Deepak Voora, Erica L. Woodahl, Michelle Whirl‐Carrillo, Akinyemi Oni‐Orisan, on behalf of the Pharmacogenomics Global Research Network (PGRN) Publications Committee   +18 more
wiley   +1 more source

A clinical study on changes of the portal pressure following hepatectomy and its background.

, 1987
Norio Suzuki, Katsuji Sakai, Hiroaki Kinoshita, Kazuhiro Hirohashi, Osamu Yamazaki   +4 more
openalex   +2 more sources

Portal vein pressure is the key for successful liver transplantation of an extremely small graft in the pig model [PDF]

, 2003
Takeshi Asakura, Nobuhiro Ohkohchi, T Orii, Nozomi Koyamada, Shigeki Tsukamoto, Masahide Sato, Yoshitaka Enomoto, Masahiro Usuda, Susumu Satomi   +8 more
openalex   +1 more source

Advancing Early Clinical Trials: The Transformative Potential of Decentralized Designs and Digital Technologies in Phase 1 Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
A Phase 1, open‐label, single‐dose, fixed‐sequence crossover study utilizing a hybrid decentralized clinical trial (DCT) design with and without practice sessions for wearable devices and PK sampling was conducted in eight healthy participants. Using etrasimod, the study assessed the feasibility of conducting a Phase 1 hybrid DCT by the Pfizer Clinical
Bimal K. Malhotra, Josué Kunjom Mfopou, Isabelle Huyghe, Pascal Ryckmans, Nathalie Severs, Anna Plotka, Kim‐Claire Tabner, Malgorzata Anna Jennes, Anand Bhuvanendran Nair, Anna Colzi   +9 more
wiley   +1 more source