Results 41 to 50 of about 340,481 (262)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Current concepts on the pathophysiology of portal hypertension

Annals of Hepatology, 2007
Cirrhosis of the liver is by far the most common cause of portal hypertension in the western world. Portal hypertension is a frequent clinical syndrome, defined by a pathological increase in the portal venous pressure.
Aina Rodríguez-Vilarrupla, Mercedes Fernández, Jaume Bosch, Joan Carles García-Pagán   +3 more
doaj   +1 more source

Endoscopic ultrasonography - emerging applications in hepatology [PDF]

, 2017
The inspection of the liver is a valuable part of the upper endoscopic ultrasonography (EUS) studies, regardless of the primary indication for the examination.
Castro, Francisca Dias de, Cotter, José Almeida Berkeley, Leite, Sílvia, Magalhães, Joana, Monteiro, Sara, Xavier, Sofia   +5 more
core   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Evolution of drainage system morphology at a land-terminating Greenland outlet glacier [PDF]

, 2012
This work was funded by the UK Natural Environment Research Council (through grants to Nienow, Mair, and Wadham, and a studentship to Bartholomew), the Edinburgh University Moss Centenary Scholarship (Cowton and Bartholomew), and a Carnegie Research ...
Alley, Bartholomaus, Bartholomew, Bartholomew, Bartholomew, Bartholomew, Behrens, Bhatia, Bingham, Collins, Collins, Cowton, Cuffey, Das, Fountain, Fountain, Fountain, Gulley, Hock, Hock, Hoffman, Howat, Hubbard, Hubbard, Iken, Iken, Iken, Kamb, Kamb, Lewis, Lliboutry, Mair, Mair, Nienow, Nienow, Palmer, Pimentel, Rignot, Röthlisberger, Schoof, Schuler, Schuler, Seaberg, Sole, Sundal, Swift, Veen, Wal, Walder, Werder, Willis, Willis, Zwally   +52 more
core   +2 more sources

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study

Acta Cirúrgica Brasileira, 2022
Introduction: Portal hypertension still represents an important health problem worldwide. In the search for knowledge regarding this syndrome, experimental studies with animal models have proven to be useful to point the direction to be taken in future ...
Fauze Maluf-Filho, Alberto Meyer, Pierre Pirchner Mathias Martins, Flávio Henrique Ferreira Galvão, Luiz Augusto Carneiro D’Albuquerque   +4 more
doaj   +1 more source

Liver transplantation in patients with patent splenorenal shunts [PDF]

, 1987
Patent distal splenorenal shunts (Warren shunt) have been reported to cause decreases in the portal perfusion pressure and the total hepatic blood flow. Such hemodynamic alterations could have adverse effects on the transplanted liver.
Esquivel, CO, Gordon, RD, Iwatsuki, S, Klintmalm, G, Makowka, L, Starzl, TE, Tzakis, A   +6 more
core  

NFDI MatWerk Ontology (MWO): A BFO‐Compliant Ontology for Research Data Management in Materials Science and Engineering

Advanced Engineering Materials, EarlyView.
This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi, Ebrahim Norouzi, Kostiantyn Hubaiev, Jörg Waitelonis, Harald Sack   +4 more
wiley   +1 more source