Results 71 to 80 of about 340,481 (262)
Advanced Therapeutics, EarlyView.This study investigates how donor age and cold ischemia time influence liver perfusion parameters and injury markers. Older livers are more susceptible to longer ischemia times displaying more tissue damage, and higher expression of oxidative stress and apoptosis‐related proteins than livers with shorter ischemia times.
Leonard Boerger +12 more
wiley +1 more source
Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture [PDF]
, 2015 A cat with a chronic diaphragmatic rupture presented with neurological signs, including twitching and focal seizures. Blood ammonia level was markedly elevated and therefore neurological signs were thought to be related to hepatic encephalopathy ...
Birchard SJ +3 more
core +3 more sources
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, EarlyView.This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
The organizational dynamics enabling patient portal impacts upon organizational performance and patient health: a qualitative study of Kaiser Permanente. [PDF]
, 2015 BackgroundPatient portals may lead to enhanced disease management, health plan retention, changes in channel utilization, and lower environmental waste.
de Bont, Antoinette +4 more
core +3 more sources
Advanced Science, EarlyView.Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu +23 more
wiley +1 more source
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, EarlyView.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
Alleviation of pressure pulse effects for trains entering tunnels. Volume 1: Summary [PDF]
The degree to which it is possible to attenuate the effects of pressure pulses on the passengers in trains entering tunnels by modifying the normally abrupt portal of a constant-diameter single track tunnel was investigated.
Dayman, B., Jr. +4 more
core +1 more source
Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]
, 1999 In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Hammer, C. +7 more
core +1 more source
Heamodynamic Doppler changes in portal pressure after trans-arterial chemoembolization of hepatocellular carcinoma. [PDF]
, 2022 Yasmine A. Ali +2 more
openalex +1 more source
Advanced Science, EarlyView.This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng +6 more
wiley +1 more source