Results 121 to 130 of about 57,438 (322)

Liposomes Containing Tetraether Lipids and Cell‐Penetrating Peptides as Platform Technology for Oral Delivery of Peptides: A Comparative Study on GLP‐1 Analogs

Nano Select, EarlyView.
Liposomes functionalized with tetraether lipids and cell‐penetrating peptides are explored as a platform technology for oral peptide delivery. Therefore, peptide drugs (GLP‐1 analogs) with different sizes and physicochemical properties are used as model drugs.
Lorenz Herbster, Giulia Pander, Manuel Ben Böhmann, Tom Eisenzapf, Sabrina Wohlfart, Eric Mühlberg, Walter Mier, Gert Fricker, Philipp Uhl   +8 more
wiley   +1 more source

The use of octreotide in pediatric patients: Practical applications for gastrointestinal disorders and beyond: A narrative review

Nutrition in Clinical Practice, EarlyView.
Abstract Somatostatin is a naturally occurring polypeptide hormone that exerts its effect on the gastrointestinal tract by reducing exocrine and endocrine secretion, resulting in decreased motility, gastric emptying, splanchnic blood flow, fat absorption, lymphatic flow, and gallbladder contraction.
Bailey Dunn, Megan Foxe, Kathy Hunter Sprott, Jessica E. Hook, Candi Jump   +4 more
wiley   +1 more source

Research Progress of Noninvasive Evaluation of Portal Hypertension by Blood‐Based Tests

Portal Hypertension & Cirrhosis
Portal hypertension (PH) is a collection of clinical conditions that occur due to an enduring elevation of pressure within the portal venous system, and it is closely linked to the prognosis of liver disease patients. The hepatic venous pressure gradient
Wei Chen, Zhi Li, Xinjie Zhang, Yanan Chen, Shirui Hao, Xiaojuan Wang, Kuopeng Liang, Jian Zhang, Dengxiang Liu, Shubo Chen, Jinlong Li   +10 more
doaj   +1 more source

Portal vein thrombosis after laparoscopic splenectomy: an ongoing clinical challenge. [PDF]

, 2005
ObjectivesPortal vein thrombosis (PVT) following open splenectomy is a potentially lethal complication with an incidence of up to 6%. The objective of this report is to describe our management of a recent laparoscopic case, discuss current therapies, and
Kee, Stephen T, Krummel, Thomas M, Mallory, Baird, Miniati, Douglas N, Padidar, Arash M   +4 more
core   +2 more sources

Complications at Diagnosis of Pediatric Chronic Myeloid Leukemia in Chronic Phase

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Chronic myeloid leukemia (CML) is uncommon during the first two decades of life, resulting in limited experience of pediatricians in handling this leukemia. This is even more true when it comes to managing rare complications at the time of diagnosis.
Nirmalya Roy Moulik, Uma Athale, Markus Metzler, Frederic Millot, Meinolf Suttorp   +4 more
wiley   +1 more source

Hepatic venous pressure gradient measurement in pre-primary and primary prophylaxis of variceal hemorrhage

Annals of Hepatology, 2013
Pharmacological therapy of portal hypertensi¢n can be accomplished according to different objectives. Among them, pre-primary prophylaxis aims to avoid / delay esophageal varices development while the target of primary prophylaxis is protection against ...
Julio D. Vorobioff, M.D., Roberto J Groszmann   +1 more
doaj  

Effects of Shunt Position on the Prognosis of Transjugular Intrahepatic Portosystemic Shunt in Patients With Cirrhotic Esophagogastric Variceal Bleeding

Portal Hypertension &Cirrhosis, EarlyView.
The challenge of transjugular intrahepatic portosystemic shunt (TIPS) remains the puncture of the portal vein. Establishing an optimal shunt position in the left branch of the portal vein would be a better option for reducing the risk of postoperative hepatic encephalopathy and stent dysfunction.
Yi‐Han Yang, Ze Wang, Chen‐Chen Lu, Wan‐Ci Li, Shuai Zhang, Jian Shen, Xiao‐Li Zhu   +6 more
wiley   +1 more source

Dihydrotanshinone I Targets PGAM1 to Induce SYVN1‐Mediated Ubiquitination and Suppress Glycolysis in Hepatocellular Carcinoma

Phytotherapy Research, EarlyView.
DHT Induced SYVN1‐Mediated PGAM1 Degradation Blocks HCC Glycolysis. ABSTRACT Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme frequently overexpressed in hepatocellular carcinoma (HCC), contributing to tumor progression through aberrant glycolysis.
Ru Xu, Jiawei Dai, Ruijie Gong, Ruoxin Tu, Qiaozi Wang, Hongdan Zheng, Li Zhou, Shusheng Wang, Jiabin Cai, Haixiang Sun, Pingting Gao, Pengfei Gao   +11 more
wiley   +1 more source

Current concepts on the pathophysiology of portal hypertension

Annals of Hepatology, 2007
Cirrhosis of the liver is by far the most common cause of portal hypertension in the western world. Portal hypertension is a frequent clinical syndrome, defined by a pathological increase in the portal venous pressure.
Aina Rodríguez-Vilarrupla, Mercedes Fernández, Jaume Bosch, Joan Carles García-Pagán   +3 more
doaj  

On the Usability of Reactive Programming APIs: A Mixed Evaluation

Software: Practice and Experience, EarlyView.
ABSTRACT Context Reactive Programming (RP) provides powerful abstractions for managing asynchronous and event‐driven behaviors, but its APIs are often perceived as complex and difficult to use, particularly due to their reliance on functional programming concepts. Objective This study investigates the usability of two prominent JavaScript RP libraries,
Carlos Zimmerle, Kiev Gama
wiley   +1 more source