Results 51 to 60 of about 63,636 (348)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Assessment of a biofluid mechanics-based model for calculating portal pressure in canines

BMC Veterinary Research, 2020
Background Portal hypertension is a severe complication caused by various chronic liver diseases. The standard methods for detecting portal hypertension (hepatic venous pressure gradient and free portal pressure) are available in only a few hospitals due
Jia-Yun Lin, Chi-Hao Zhang, Lei Zheng, Chen-Lu Song, Wen-Sheng Deng, Yi-Ming Zhu, Li Zheng, Li-Zhong Wu, Long-Ci Sun, Meng Luo   +9 more
doaj   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Gastric pneumatosis in a child with congenital duodenal obstruction

Journal of Pediatric Surgery Case Reports, 2022
Pneumatosis of the foregut is an extremely rare finding which may indicate a potentially serious condition. In newborn the presence of gastric intramural gas is mainly associated to necrotizing enterocolitis and is considered a condition which correlates
Alberto Ratta, Simona Straziuso, Lorenzo De Biagi, Veronica Carlini, Francesco Muratore, Vincenzo Domenichelli   +5 more
doaj   +1 more source

Portal Venous Thrombosis Associated with Use of Etonogestrel/ethinyl Estradiol Vaginal Ring [PDF]

, 2020
Introduction: Portal venous thrombosis is a life-threatening cause of abdominal pain. In younger patients, heritable thrombophilias, pregnancy, tobacco use, and oral contraceptives are associated.Case Report: A 26-year-old woman prescribed contraceptive ...
Bailey, Katelynn E., Tranovich, Michael J.   +1 more
core  

Hepatic infarction following abdominal interventional procedures. [PDF]

, 2004
To clarify the incidence, background, and progress of hepatic infarction following interventional procedures, cases of hepatic infarction following interventional procedures at our department during the last decade were identified by reviewing the ...
Akaki, Shiro, Fujiwara, Hiroyasu, Hiraki, Takao, Hiraki, Yoshio, Kanazawa, Susumu, Mimura, Hidefumi, Naomoto, Yoshio, Tanaka, Noriaki, Yagi, Takahito, Yasui, Kotaro   +9 more
core   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo   +23 more
wiley   +1 more source

Analyzing the human liver vascular architecture by combining vascular corrosion casting and micro-CT scanning: a feasibility study [PDF]

, 2014
Although a full understanding of the hepatic circulation is one of the keys to successfully perform liver surgery and to elucidate liver pathology, relatively little is known about the functional organization of the liver vasculature.
Casteleyn, Christophe, Cornillie, Pieter, Debbaut, Charlotte, Dierick, Manuel, Laleman, Wim, Monbaliu, Diethard, Segers, Patrick   +6 more
core   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure. [PDF]

PLoS ONE, 2013
OBJECTIVE: Only a limited proportion of patients needing pharmacological control of portal hypertension are hemodynamic responders to propranolol.
Mercedes Reboredo, Haisul C Y Chang, Roberto Barbero, Carlos M Rodríguez-Ortigosa, Francisco Pérez-Vizcaíno, Asunción Morán, Mónica García, Jesús M Banales, Norberto Carreño, Félix Alegre, Ignacio Herrero, Jorge Quiroga, Jesús Prieto, Bruno Sangro   +13 more
doaj   +1 more source